ArticleCold Spring Harbor molecular case studies2016
A novel TP53-KPNA3 translocation defines a de novo treatment-resistant clone in osteosarcoma.
Article in Cold Spring Harbor molecular case studies, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Article
- An overview of resistance to chemotherapy in osteosarcoma and future perspectives.Cancer drug resistance (Alhambra, Calif.) · 2022Review
- RGB-Marking to Identify Patterns of Selection and Neutral Evolution in Human Osteosarcoma Models.Cancers · 2021Article
- Biology and pathogenesis of human osteosarcoma.Oncology letters · 2020Review
- Clonal dynamics in osteosarcoma defined by RGB marking.Nature communications · 2018Article
- Recurrent rearrangements of FOS and FOSB define osteoblastoma.Nature communications · 2018Article
- Osteosarcoma: Molecular Pathogenesis and iPSC Modeling.Trends in molecular medicine · 2017Review
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11 authors.
Funding
Abstract
Osteosarcoma is the most common primary bone cancer. It can be cured by aggressive surgery and chemotherapy, but outcomes for metastatic or chemoresistant disease remain dismal. Cancer sequencing studies have shown that the p53 pathway is dysregulated in nearly every case, often by translocation; however, no studies of osteosarcoma evolution or intratumor heterogeneity have been done to date. We studied a patient with chemoresistant, metastatic disease over the course of 3 years. We performed exome sequencing on germline DNA and DNA collected from tumor at three separate time points. We compared variant calls and variant allele frequencies between different samples. We identified subclonal mutations in several different genes in the primary tumor sample and found that one particular subclone dominated subsequent tumor samples at relapse. This clone was marked by a novel TP53-KPNA3 translocation and loss of the opposite-strand wild-type TP53 allele. Future research must focus on the functional significance of such clones and strategies to eliminate them.
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