ArticleTemperature (Austin, Tex.)
Effects of MDMA on body temperature in humans.
Article in Temperature (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- Comparison of acute effects of 3,4-methylenedioxymethamphetamine (MDMA) with and without a supplemental booster dose in healthy participants: a double-blind, randomized, placebo-controlled, crossover study.Translational psychiatry · 2026Trial
- Safety pharmacology of acute LSD administration in healthy subjects.Psychopharmacology · 2022Trial
- The intersection between psychedelics and schizophrenia spectrum disorders: Reevaluating risk and therapeutic potential.Journal of psychopharmacology (Oxford, England) · 2026Review
- Exploring MDMA assisted therapy in eating disorders: mechanisms, clinical evidence, and future directions.Journal of eating disorders · 2025Review
- The effect of MDMA on anterior pituitary hormones: a secondary analysis of a randomized placebo-controlled trial.Endocrine connections · 2025Article
- Exploring the Nexus of Climate Change and Substance Abuse: A Scoping Review.International journal of environmental research and public health · 2024Article
- Associations between short-term ambient temperature exposure and emergency department visits for amphetamine, cocaine, and opioid use in California from 2005 to 2019.Environment international · 2023Article
- Balancing Therapeutic Efficacy and Safety of MDMA and Novel MDXX Analogues as Novel Treatments for Autism Spectrum Disorder.Psychedelic medicine (New Rochelle, N.Y.) · 2023Review
- Dantrolene sodium fails to reverse robust brain hyperthermia induced by MDMA and methamphetamine in rats.Psychopharmacology · 2023Article
- The Emerging Field of Psychedelic Psychotherapy.Current psychiatry reports · 2022Review
- Physiological Changes in Subjects Exposed to Accidental Hypothermia: An Update.Frontiers in medicine · 2022Review
- Dantrolene Administration in the Management of the Prehospital Patient with Methylenedioxymethamphetamine Overdose: A Case Series and Literature Review.Case reports in critical care · 2022Article
- Worsening of the Toxic Effects of (±)International journal of molecular sciences · 2021Article
- Prediction of MDMA response in healthy humans: a pooled analysis of placebo-controlled studies.Journal of psychopharmacology (Oxford, England) · 2021Article
- Discontinuation of medications classified as reuptake inhibitors affects treatment response of MDMA-assisted psychotherapy.Psychopharmacology · 2021Article
- Self-reported PTSD is associated with increased use of MDMA in adolescents with substance use disorders.European journal of psychotraumatology · 2021Article
- Protracted hyperthermia and delayed rhabdomyolysis in ecstasy toxicity: A case report.Medicine · 2020Article
- Zinc attenuates ecstasy-induced apoptosis through downregulation of caspase-3 in cultured TM3 cells: An experimental study.International journal of reproductive biomedicine · 2020Article
- Article
- The acute toxic and neurotoxic effects of 3,4-methylenedioxymethamphetamine are more pronounced in adolescent than adult mice.Behavioural brain research · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperthermia is a severe complication associated with the recreational use of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy). In this review, the clinical laboratory studies that tested the effects of MDMA on body temperature are summarized. The mechanisms that underlie the hyperthermic effects of MDMA in humans and treatment of severe hyperthermia are presented. The data show that MDMA produces an acute and dose-dependent rise in core body temperature in healthy subjects. The increase in body temperature is in the range of 0.2-0.8°C and does not result in hyperpyrexia (>40°C) in a controlled laboratory setting. However, moderately hyperthermic body temperatures >38.0°C occur frequently at higher doses, even in the absence of physical activity and at room temperature. MDMA primarily releases serotonin and norepinephrine. Mechanistic clinical studies indicate that the MDMA-induced elevations in body temperature in humans partially depend on the MDMA-induced release of norepinephrine and involve enhanced metabolic heat generation and cutaneous vasoconstriction, resulting in impaired heat dissipation. The mediating role of serotonin is unclear. The management of sympathomimetic toxicity and associated hyperthermia mainly includes sedation with benzodiazepines and intravenous fluid replacement. Severe hyperthermia should primarily be treated with additional cooling and mechanical ventilation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.