Evidence map›Paper›PMID 27625997›Full record

ReviewFrontiers in cellular and infection microbiology2016

Gut Microbiota: A Contributing Factor to Obesity.

Steve M Harakeh, Imran Khan, Taha Kumosani, Elie Barbour, Saad B Almasaudi, Suhad M Bahijri, Sulaiman M Alfadul, Ghada M A Ajabnoor, Esam I Azhar

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 103 citations in OpenAlex.

  1. Effects ofNutrients · 2022
    Trial
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Identifying gut microbiotaFrontiers in microbiology · 2025
    Article
  12. Review
  13. Article
  14. Protective Effects ofInternational journal of molecular sciences · 2023
    Article
  15. Review
  16. Analysis of gut bacteriome ofFrontiers in microbiology · 2023
    Article
  17. Antibiofilm Activity ofLife (Basel, Switzerland) · 2022
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Steve M HarakehSpecial Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University Jeddah, Saudi Arabia.
Imran KhanSpecial Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz UniversityJeddah, Saudi Arabia; Department of Biochemistry, Faculty of Science, King Abdulaziz UniversityJeddah, Saudi Arabia.
Taha KumosaniDepartment of Biochemistry, Faculty of Science, King Abdulaziz UniversityJeddah, Saudi Arabia; Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz UniversityJeddah, Saudi Arabia.
Elie BarbourDepartment of Animal and Veterinary Sciences, Faculty of Agricultural and Food Sciences, American University of BeirutBeirut, Lebanon; Department of Biochemistry, Faculty of Science, King Abdulaziz UniversityJeddah, Saudi Arabia.
Saad B AlmasaudiBiology Department, Faculty of Science, King Abdulaziz University Jeddah, Saudi Arabia.
Suhad M BahijriClinical Biochemistry Department, College of Medicine, Nutrition Unit-King Fahd Medical Research Center, King Abdulaziz University Jeddah, Saudi Arabia.
Sulaiman M AlfadulKing Abdulaziz City for Science and Technology Riyadh, Saudi Arabia.
Ghada M A AjabnoorClinical Biochemistry Department, College of Medicine, Nutrition Unit-King Fahd Medical Research Center, King Abdulaziz University Jeddah, Saudi Arabia.
Esam I AzharSpecial Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz UniversityJeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Science, King Abdulaziz UniversityJeddah, Saudi Arabia.
King Abdulaziz University · SAKing Abdulaziz City for Science and Technology · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity, a global epidemic of the modern era, is a risk factor for cardiovascular diseases (CVD) and diabetes. The pervasiveness of obesity and overweight in both developed as well as developing populations is on the rise and placing a huge burden on health and economic resources. Consequently, research to control this emerging epidemic is of utmost importance. Recently, host interactions with their resident gut microbiota (GM) have been reported to be involved in the pathogenesis of many metabolic diseases, including obesity, diabetes, and CVD. Around 10(14) microorganisms reside within the lower human intestine and many of these 10(14) microorganisms have developed mutualistic or commensal associations with the host and actively involved in many physiological processes of the host. However, dysbiosis (altered gut microbial composition) with other predisposing genetic and environmental factors, may contribute to host metabolic disorders resulting in many ailments. Therefore, delineating the role of GM as a contributing factor to obesity is the main objective of this review. Obesity research, as a field is expanding rapidly due to major advances in nutrigenomics, metabolomics, RNA silencing, epigenetics, and other disciplines that may result in the emergence of new technologies and methods to better interpret causal relationships between microbiota and obesity.

Indexed as

Gastrointestinal MicrobiomeAnimalsDysbiosisGastrointestinal TractHumansObesityfoodGM-obesity dilemagut microbiotaobesitySaudi Arabia

Identifiers

PMID27625997
PMCPMC5003832
OpenAlexW2508101514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.