Evidence map›Paper›PMID 27625988›Full record

ArticleNeuroImage. Clinical2016

Psychological intervention with working memory training increases basal ganglia volume: A VBM study of inpatient treatment for methamphetamine use.

S J Brooks, K H Burch, S A Maiorana, E Cocolas, H B Schioth, E K Nilsson, K Kamaloodien, D J Stein

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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  10. The Effects of Working Memory versus Adaptive Visual Search Control Training on Executive Cognitive Function.Journal of cognitive enhancement : towards the integration of theory and practice · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

S J BrooksDepartment of Psychiatry and Mental Health, Groote Schuur Hospital and University of Cape Town, MRC Unit on Anxiety and Stress Disorders, South Africa.
K H BurchDepartment of Psychiatry and Mental Health, Groote Schuur Hospital and University of Cape Town, MRC Unit on Anxiety and Stress Disorders, South Africa; Department of Neuroscience, University of Nottingham, UK.
S A MaioranaDepartment of Psychology, University of Cape Town, South Africa.
E CocolasDepartment of Psychiatry and Mental Health, Groote Schuur Hospital and University of Cape Town, MRC Unit on Anxiety and Stress Disorders, South Africa.
H B SchiothDepartment of Neuroscience, Uppsala University, Sweden.
E K NilssonDepartment of Neuroscience, Uppsala University, Sweden.
K KamaloodienDepartment of Psychology, University of the Western Cape, Bellville, Cape Town, South Africa.
D J SteinDepartment of Psychiatry and Mental Health, Groote Schuur Hospital and University of Cape Town, MRC Unit on Anxiety and Stress Disorders, South Africa.
Groote Schuur Hospital · ZAUppsala University · SEUniversity of Cape Town · ZAUniversity of the Western Cape · ZA

Funding

Combating craving with contingency management: neuroplasticity and methamphetamine abuse in South AfricaR21DA040492 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHOPTAW, STEVEN J · 2015 to 2017
$311k
NIDA NIH HHS R21 DA040492
6 · The paper itself

Abstract

backgroundProtracted methamphetamine (MA) use is associated with decreased control over drug craving and altered brain volume in the frontostriatal network. However, the nature of volumetric changes following a course of psychological intervention for MA use is not yet known.

methods66 males (41 MA patients, 25 healthy controls, HC) between the ages of 18-50 were recruited, the MA patients from new admissions to an in-patient drug rehabilitation centre and the HC via public advertisement, both in Cape Town, South Africa. 17 MA patients received 4 weeks of treatment as usual (TAU), and 24 MA patients completed TAU plus daily 30-minute cognitive training (CT) using an N-back working memory task. Magnetic resonance imaging (MRI) at baseline and 4-week follow-up was acquired and voxel-based morphometry (VBM) was used for analysis.

resultsTAU was associated with larger bilateral striatum (caudate/putamen) volume, whereas CT was associated with more widespread increases of the bilateral basal ganglia (incorporating the amygdala and hippocampus) and reduced bilateral cerebellum volume coinciding with improvements in impulsivity scores.

conclusionsWhile psychological intervention is associated with larger volume in mesolimbic reward regions, the utilisation of additional working memory training as an adjunct to treatment may further normalize frontostriatal structure and function.

Indexed as

AdolescentAdultBasal GangliaCentral Nervous System StimulantsHumansImpulsive BehaviorInpatientsMaleMemory, Short-TermMethamphetamineMiddle AgedNeuropsychological TestsSubstance-Related DisordersTreatment OutcomeYoung AdultCentral Nervous System StimulantsMethamphetamine

Identifiers

PMID27625988
PMCPMC5011179
OpenAlexW2512173367

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.