Evidence map›Paper›PMID 27625900›Full record

ArticleTremor and other hyperkinetic movements (New York, N.Y.)2016

Predicting Improvement in Writer's Cramp Symptoms following Botulinum Neurotoxin Injection Therapy.

Mallory Jackman, Mehdi Delrobaei, Fariborz Rahimi, S Farokh Atashzar, Mahya Shahbazi, Rajni Patel, Mandar Jog

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tremor and other hyperkinetic movements (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Mallory JackmanLawson Health Research Institute, London, ON, Canada.
Mehdi DelrobaeiFaculty of Electrical Engineering, K. N. Toosi University of Technology, Tehran, Iran.
Fariborz RahimiDepartment of Electrical and Computer Engineering, Bonab University, Bonab, East Azerbaijan, Iran.
S Farokh AtashzarDepartment of Electrical and Computer Engineering, Western University, London, ON, Canada.
Mahya ShahbaziDepartment of Electrical and Computer Engineering, Western University, London, ON, Canada.
Rajni PatelLawson Health Research Institute, London, ON, Canada; Department of Electrical and Computer Engineering, Western University, London, ON, Canada.
Mandar JogLawson Health Research Institute, London, ON, Canada; Department of Clinical Neurological Sciences, Western University, London, ON, Canada.
Western University · CAK.N.Toosi University of Technology · IRLawson Health Research Institute · CAUniversity of Bonab · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWriter's cramp is a specific focal hand dystonia causing abnormal posturing and tremor in the upper limb. The most popular medical intervention, botulinum neurotoxin type A (BoNT-A) therapy, is variably effective for 50-70% of patients. BoNT-A non-responders undergo ineffective treatment and may experience significant side effects. Various assessments have been used to determine response prediction to BoNT-A, but not in the same population of patients.

methodsA comprehensive assessment was employed to measure various symptom aspects. Clinical scales, full upper-limb kinematic measures, self-report, and task performance measures were assessed for nine writer's cramp patients at baseline. Patients received two BoNT-A injections then were classified as responders or non-responders based on a quantified self-report measure. Baseline scores were compared between groups, across all measures, to determine which scores predicted a positive BoNT-A response.

resultsFive of nine patients were responders. No kinematic measures were predictably different between groups. Analyses revealed three features that predicted a favorable response and separated the two groups: higher than average cramp severity and cramp frequency, and below average cramp latency. DISCUSSION: Non-kinematic measures appear to be superior in making such predictions. Specifically, measures of cramp severity, frequency, and latency during performance of a specific set of writing and drawing tasks were predictive factors. Since kinematic was not used to determine the injection pattern and the injections were visually guided, it may still be possible to use individual patient kinematics for better outcomes.

Indexed as

botulinum toxinfocal hand dystoniakinematicsWriter’s cramp

Identifiers

PMID27625900
PMCPMC5013165
OpenAlexW2520196053

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.