ArticleSurgical neurology international2016
Biocompatibility of reduced graphene oxide nanoscaffolds following acute spinal cord injury in rats.
Article in Surgical neurology international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Engineered Healing: Synergistic Use of Schwann Cells and Biomaterials for Spinal Cord Regeneration.International journal of molecular sciences · 2025Review
- Graphene oxide scaffolds promote functional improvements mediated by scaffold-invading axons in thoracic transected rats.Bioactive materials · 2025Article
- Application of Adipose Extracellular Matrix and Reduced Graphene Oxide Nanocomposites for Spinal Cord Injury Repair.Advanced healthcare materials · 2025Article
- Preparation of PDA-GO/CS composite scaffold and its effects on the biological properties of human dental pulp stem cells.BMC oral health · 2024Article
- Current Concepts of Biomaterial Scaffolds and Regenerative Therapy for Spinal Cord Injury.International journal of molecular sciences · 2023Review
- Graphene and graphene-based materials in axonal repair of spinal cord injury.Neural regeneration research · 2022Review
- Graphene-based nanomaterials for cancer therapy and anti-infections.Bioactive materials · 2022Review
- Modulation of Conductivity of Alginate Hydrogels Containing Reduced Graphene Oxide through the Addition of Proteins.Pharmaceutics · 2021Article
- Graphene oxide-composited chitosan scaffold contributes to functional recovery of injured spinal cord in rats.Neural regeneration research · 2021Article
- Benefits in the Macrophage Response Due to Graphene Oxide Reduction by Thermal Treatment.International journal of molecular sciences · 2021Article
- rGO/Silk Fibroin-Modified Nanofibrous Patches Prevent Ventricular RemodelingFrontiers in cardiovascular medicine · 2021Article
- Hydrogels for neuroprotection and functional rewiring: a new era for brain engineering.Neural regeneration research · 2020Review
- Biomaterials to Neuroprotect the Stroke Brain: A Large Opportunity for Narrow Time Windows.Cells · 2020Review
- Fuzzy Logic and Bio-Inspired Firefly Algorithm Based Routing Scheme in Intrabody Nanonetworks.Sensors (Basel, Switzerland) · 2019Article
- Reduced Graphene Oxide Incorporated GelMA Hydrogel Promotes Angiogenesis For Wound Healing Applications.International journal of nanomedicine · 2019Article
- Translational Regenerative Therapies for Chronic Spinal Cord Injury.International journal of molecular sciences · 2018Review
- Development of Self-Assembled Nanoribbon Bound Peptide-Polyaniline Composite Scaffolds and Their Interactions with Neural Cortical Cells.Bioengineering (Basel, Switzerland) · 2018Article
- Nanofiber Scaffolds as Drug Delivery Systems to Bridge Spinal Cord Injury.Pharmaceuticals (Basel, Switzerland) · 2017Review
- The impact of graphene on neural regenerative medicine.Neural regeneration research · 2017Article
- Immunohistochemical evidence of axonal regrowth across polyethylene glycol-fused cervical cords in mice.Neural regeneration research · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGraphene has unique electrical, physical, and chemical properties that may have great potential as a bioscaffold for neuronal regeneration after spinal cord injury. These nanoscaffolds have previously been shown to be biocompatible in vitro; in the present study, we wished to evaluate its biocompatibility in an in vivo spinal cord injury model.
methodsGraphene nanoscaffolds were prepared by the mild chemical reduction of graphene oxide. Twenty Wistar rats (19 male and 1 female) underwent hemispinal cord transection at approximately the T2 level. To bridge the lesion, graphene nanoscaffolds with a hydrogel were implanted immediately after spinal cord transection. Control animals were treated with hydrogel matrix alone. Histologic evaluation was performed 3 months after the spinal cord transection to assess in vivo biocompatibility of graphene and to measure the ingrowth of tissue elements adjacent to the graphene nanoscaffold.
resultsThe graphene nanoscaffolds adhered well to the spinal cord tissue. There was no area of pseudocyst around the scaffolds suggestive of cytotoxicity. Instead, histological evaluation showed an ingrowth of connective tissue elements, blood vessels, neurofilaments, and Schwann cells around the graphene nanoscaffolds.
conclusionsGraphene is a nanomaterial that is biocompatible with neurons and may have significant biomedical application. It may provide a scaffold for the ingrowth of regenerating axons after spinal cord injury.
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