ArticleFrontiers in pharmacology2016
Effects of Telephone Counseling Intervention by Pharmacists (TelCIP) on Medication Adherence; Results of a Cluster Randomized Trial.
Article in Frontiers in pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Systematic review of pragmatic randomised control trials assessing the effectiveness of professional pharmacy services in community pharmacies.BMC health services research · 2021Pooled it
- Effect of Interactive eHealth Interventions on Improving Medication Adherence in Adults With Long-Term Medication: Systematic Review.Journal of medical Internet research · 2021Pooled it
- 2019 EULAR points to consider for non-physician health professionals to prevent and manage fragility fractures in adults 50 years or older.Annals of the rheumatic diseases · 2021Guideline
- Pooled it
- Pharmacy-based management for depression in adults.The Cochrane database of systematic reviews · 2019Pooled it
- Implementation fidelity of an intervention programme to enhance adherence to antihypertensive medication in Dutch community pharmacies.International journal of clinical pharmacy · 2019Trial
- Tailoring the CFIR to Medication Adherence Interventions: A Delphi and Living Lab Study.Pharmacy (Basel, Switzerland) · 2026Article
- Role of pharmacists in HIV prophylaxis: a scoping review of pharmacists' services, interventions and outcomes.Journal of the International AIDS Society · 2026Article
- Interventions to improve adherence to lipid-lowering drugs: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Drug-related problems experienced by rheumatoid arthritis patients during the first three months of methotrexate use: a longitudinal observational study.International journal of clinical pharmacy · 2025Observational
- Pharmacist-led new medicine service: a real-world cohort study in the Netherlands on drug-related problems, satisfaction, and self-efficacy in cardiovascular patients transitioning to primary care.International journal of clinical pharmacy · 2025Article
- A study protocol for exploring and implementing a surgical pharmaceutical service model in drug treatment management for patients with osteoporosis fracture in China.Frontiers in medicine · 2025Article
- Interventions to Expand Community Pharmacists' Scope of Practice.Pharmacy (Basel, Switzerland) · 2024Review
- Evolving Management of Low-Density Lipoprotein Cholesterol: A Personalized Approach to Preventing Atherosclerotic Cardiovascular Disease Across the Risk Continuum.Journal of the American Heart Association · 2023Review
- Using the Simulated Patient Methodology in the Form of Mystery Calls in Community Pharmacy Practice Research: A Scoping Review Protocol.Pharmacy (Basel, Switzerland) · 2023Article
- Assessing Pharmacy Student Performance and Perceptions on Counseling Skills Through a Simulated Telehealth Encounter.American journal of pharmaceutical education · 2022Article
- Impact of physician' and pharmacy staff supporting activities in usual care on patients' statin adherence.PloS one · 2022Article
- Impact of the COVID-19 epidemic on the provision of pharmaceutical care in community pharmacies.Research in social & administrative pharmacy : RSAP · 2021Article
- The impact of COVID-19 on pharmacy transitions of care services.Research in social & administrative pharmacy : RSAP · 2021Article
- Using Simulation to Teach Methods for Improving Patient Literacy about Medicines.Pharmacy (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the effect of a pharmacist telephone counseling intervention on patients' medication adherence.
designPragmatic cluster randomized controlled trial.
setting53 Community pharmacies in The Netherlands.
participantsPatients ≥18 years initiating treatment with antidepressants, bisphosphonates, Renin-Angiotensin System (RAS)-inhibitors, or statins (lipid lowering drugs). Pharmacies in arm A provided the intervention for antidepressants and bisphosphonates and usual care for RAS-inhibitors and statins. Pharmacies in arm B provided the intervention for RAS-inhibitors and statins and usual care for antidepressants and bisphosphonates.
interventionINTERVENTION consisted of a telephone counseling intervention 7-21 days after the start of therapy. Counseling included assessment of practical and perceptual barriers and provision of information and motivation.
main outcome measurePrimary outcome was refill adherence measured over 1 year expressed as continuous outcome and dichotomous (refill rate≥80%). Secondary outcome was discontinuation within 1 year.
resultsIn the control arms 3627 patients were eligible and in the intervention arms 3094 patients. Of the latter, 1054 patients (34%) received the intervention. Intention to treat analysis showed no difference in adherence rates between the intervention and the usual care arm (74.7%, SD 37.5 respectively 74.5%, 37.9). More patients starting with RAS-inhibitors had a refill ratio ≥80% in the intervention arm compared to usual care (81.4 vs. 74.9% with odds ratio (OR) 1.43, 95%CI 1.11-1.99). Comparing patients with counseling to patients with usual care (per protocol analysis), adherence was statistically significant higher for patients starting with RAS-inhibitors, statins and bisphosphonates. Patients initiating antidepressants did not benefit from the intervention.
conclusionsTelephone counseling at start of therapy improved adherence in patients initiating RAS-inhibitors. The per protocol analysis indicated an improvement for lipid lowering drugs and bisphosphonates. No effect for on adherence in patients initiating antidepressants was found. The trial was registered at www.trialregister.nl under the identifier NTR3237.
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