ReviewThe Journal of infectious diseases2016
From Wasting to Obesity: The Contribution of Nutritional Status to Immune Activation in HIV Infection.
Review in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Trial
- Trial
- Prevalence and determinants of cardiometabolic comorbidities among people living with HIV receiving antiretroviral therapy at Zewditu Memorial Hospital: evidence from Ethiopia's longest serving AIDS clinic.BMC infectious diseases · 2026Article
- Nutritional Status of Adult People Living with HIV: A Narrative Review.Diseases (Basel, Switzerland) · 2025Review
- Article
- Development of Hypertension and Diabetes Mellitus, and Associated Factors, Among Adult HIV Patients in Ethiopia.HIV/AIDS (Auckland, N.Z.) · 2023Article
- Article
- Hypoalbuminemia predicts inferior outcome in patients with AIDS-related lymphoma.Infectious agents and cancer · 2022Article
- HIV Symptom Clusters are Similar Using the Dimensions of Symptom Occurrence and Distress.Journal of pain and symptom management · 2022Article
- Non-communicable disease risk factors among people living with HIV/AIDS (PLHA) - A relook during the covid-19 pandemic.Journal of family medicine and primary care · 2022Article
- Association between CD4BMC infectious diseases · 2021Article
- Undernutrition and HIV Infection in Sub-Saharan Africa: Health Outcomes and Therapeutic Interventions.Current HIV/AIDS reports · 2021Review
- Immune activation and arterial stiffness in lean adults with HIV on antiretroviral therapy.Southern African journal of HIV medicine · 2021Article
- Evaluation of dyspnea of unknown etiology in HIV patients with cardiopulmonary exercise testing and cardiovascular magnetic resonance imaging.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Article
- The Effect of Community-Based Nutritional Interventions on Children of Women Living With Human Immunodeficiency Virus in Rural India: A 2 × 2 Factorial Intervention Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Combined effects of HIV and obesity on the gastrointestinal microbiome of young men who have sex with men.HIV medicine · 2020Article
- Household Food Insecurity as Mediator of the Association Between Internalized Stigma and Opportunistic Infections.AIDS and behavior · 2018Article
- Metabolically Healthy or Metabolically Unhealthy Obese HIV-Infected Patients: Mostly a Matter of Age?Frontiers in endocrinology · 2018Article
- Ghrelin, Amylin, Gastric Inhibitory Peptide and Cognition in Middle-Aged HIV-Infected and Uninfected Women: The Women's Interagency HIV Study.Journal of neurology & neurophysiology · 2017Article
- Body Composition and Metabolic Syndrome Components on Lipodystrophy Different Subtypes Associated with HIV.Journal of nutrition and metabolism · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
The impact of human immunodeficiency virus (HIV) infection on innate and adaptive immune activation occurs in the context of host factors, which serve to augment or dampen the physiologic response to the virus. Independent of HIV infection, nutritional status, particularly body composition, affects innate immune activation through a variety of conditions, including reduced mucosal barrier defenses and microbiome dysbiosis in malnutrition and the proinflammatory contribution of adipocytes and stromal vascular cells in obesity. Similarly, T-cell activation, proliferation, and cytokine expression are reduced in the setting of malnutrition and increased in obesity, potentially due to adipokine regulatory mechanisms restraining energy-avid adaptive immunity in times of starvation and exerting a paradoxical effect in overnutrition. The response to HIV infection is situated within these complex interactions between host nutritional health and immunologic function, which contribute to the varied phenotypes of immune activation among HIV-infected patients across a spectrum from malnutrition to obesity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.