ArticleProceedings of the National Academy of Sciences of the United States of America2016
Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
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- Modulation of antibody transport in the brain and spinal cord through the intranasal pathway.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice.Nature neuroscience · 2024Article
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- Contactin-6-deficient male mice exhibit the abnormal function of the accessory olfactory system and impaired reproductive behavior.Brain and behavior · 2023Article
- CRISPR/Cas9-generated mouse model with humanizing single-base substitution in theFrontiers in genome editing · 2023Article
- Mapping transgene insertion sites reveals the α-Cre transgene expression in both developing retina and olfactory neurons.Communications biology · 2022Article
- Neural and Hormonal Basis of Opposite-Sex Preference by Chemosensory Signals.International journal of molecular sciences · 2021Review
- Cell Type-specific Knockout withExperimental neurobiology · 2021Article
- Inhibitory signaling in mammalian olfactory transduction potentially mediated by GαMolecular and cellular neurosciences · 2021Article
- Cellular Diversity and Differential Subcellular Localization of the G-Protein GFrontiers in neuroanatomy · 2021Article
- Humanization ofBiomedicines · 2020Article
- Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice.Molecular brain · 2019Article
- Gene Expression Profile of Olfactory Transduction Signaling in an Animal Model of Human Multiple Sclerosis.Experimental neurobiology · 2019Article
- G protein γ subunit Gγ13 is essential for olfactory function and aggressive behavior in mice.Neuroreport · 2018Article
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
In mammals, initial detection of olfactory stimuli is mediated by sensory neurons in the main olfactory epithelium (MOE) and the vomeronasal organ (VNO). The heterotrimeric GTP-binding protein Go is widely expressed in the MOE and VNO of mice. Early studies indicated that Go expression in VNO sensory neurons is critical for directing social and sexual behaviors in female mice [Oboti L, et al. (2014) BMC Biol 12:31]. However, the physiological functions of Go in the MOE have remained poorly defined. Here, we examined the role of Go in the MOE using mice lacking the α subunit of Go Development of the olfactory bulb (OB) was perturbed in mutant mice as a result of reduced neurogenesis and increased cell death. The balance between cell types of OB interneurons was altered in mutant mice, with an increase in the number of tyrosine hydroxylase-positive interneurons at the expense of calbindin-positive interneurons. Sexual behavior toward female mice and preference for female urine odors by olfactory sensory neurons in the MOE were abolished in mutant male mice. Our data suggest that Go signaling is essential for the structural and functional integrity of the MOE and for specification of OB interneurons, which in turn are required for the transmission of pheromone signals and the initiation of mating behavior with the opposite sex.
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