Evidence map›Paper›PMID 27625345›Full record

ArticleJournal of the American Heart Association2016

Associations Between Macrophage Colony-Stimulating Factor and Monocyte Chemotactic Protein 1 in Plasma and First-Time Coronary Events: A Nested Case-Control Study.

Alexandru Schiopu, Eva Bengtsson, Isabel Gonçalves, Jan Nilsson, Gunilla Nordin Fredrikson, Harry Björkbacka

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alexandru SchiopuDepartment of Clinical Sciences Malmö, Lund University, Sweden Cardiology Unit, Skane University Hospital, Malmö, Sweden alexandru.schiopu@med.lu.se.
Eva BengtssonDepartment of Clinical Sciences Malmö, Lund University, Sweden.
Isabel GonçalvesDepartment of Clinical Sciences Malmö, Lund University, Sweden Cardiology Unit, Skane University Hospital, Malmö, Sweden.
Jan NilssonDepartment of Clinical Sciences Malmö, Lund University, Sweden.
Gunilla Nordin FredriksonDepartment of Clinical Sciences Malmö, Lund University, Sweden.
Harry BjörkbackaDepartment of Clinical Sciences Malmö, Lund University, Sweden.
Lund University · SESkåne University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyeloid cells play a central role in atherosclerosis. We investigated the associations between the plasma levels of growth factors and chemokines that regulate myeloid cell homeostasis and function and the risk of first-time acute coronary events in middle-aged persons. METHODS AND

resultsWe measured baseline plasma levels of macrophage colony-stimulating factor; monocyte chemotactic protein 1; C-C motif chemokine ligands 3, 4, and 20; C-X-C motif chemokine ligands 1, 6, and 16; and C-X3-C motif chemokine ligand 1 in 292 participants who had a coronary event during follow-up and 366 controls matched for age, sex, and time of inclusion who remained event free. Study participants were recruited from the Malmö Diet and Cancer Study population cohort and had no previous history of coronary artery disease. We found a strong independent negative association between macrophage colony-stimulating factor and incident coronary events in a forward stepwise Cox proportional hazards model including all biomarkers alongside the classic Framingham risk factors (age, sex, smoking, total cholesterol, high-density lipoprotein cholesterol, systolic blood pressure), diabetes mellitus, and medication. Conversely, monocyte chemotactic protein 1 had the strongest independent positive association with the outcome. The addition of macrophage colony-stimulating factor and monocyte chemotactic protein 1 significantly improved the predictive ability of a model including traditional risk factors alone (C statistic 0.81 [95% CI 0.78-0.84] versus 0.67 [95% CI 0.63-0.71]; net reclassification index 0.52 [0.42-0.62]; P<0.001). The combined model led to a 54% net downclassification of participants who did not have a coronary event during follow-up and was particularly effective in the intermediate-risk group.

conclusionsHigh levels of macrophage colony-stimulating factor and low levels of monocyte chemotactic protein 1 in plasma characterize middle-aged persons at low risk to develop clinically manifested coronary artery disease.

Indexed as

AgedCase-Control StudiesChemokine CCL2Chemokine CCL20Chemokine CCL3Chemokine CCL4Chemokine CX3CL1Chemokine CXCL1Chemokine CXCL16Chemokine CXCL6Cohort StudiesFemaleHumansMacrophage Colony-Stimulating FactorMaleMiddle AgedCCL20 protein, humanCCL2 protein, humanCCL3 protein, humanCCL4 protein, humanChemokine CCL2Chemokine CCL20Chemokine CCL3Chemokine CCL4Chemokine CX3CL1Chemokine CXCL1Chemokine CXCL16Chemokine CXCL6CX3CL1 protein, humanCXCL16 protein, humanCXCL1 protein, humanCXCL6 protein, humanMacrophage Colony-Stimulating Factorcoronary artery diseaseinflammationinnate immunityleukocytesmacrophage colony‐stimulating factormonocyte chemotactic protein 1

Identifiers

PMID27625345
PMCPMC5079003
OpenAlexW2519028360

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.