ArticleDrug metabolism and disposition: the biological fate of chemicals2016
Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2',5'-Tetrachlorobiphenyl.
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Article in Drug metabolism and disposition: the biological fate of chemicals, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
4.7field-weighted citation impact, top 6% of its field
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24 citing papers in PubMed, 34 citations in OpenAlex.
- Identification of polychlorinated biphenyls (PCBs) and PCB metabolites associated with changes in the gut microbiome of female mice exposed to an environmental PCB mixture.Journal of hazardous materials · 2025Article
- Article
- Inhalation of 2,2',5,5'-tetrachlorobiphenyl (PCB52) causes changes to the gut microbiome throughout the gastrointestinal tract.Journal of hazardous materials · 2024Article
- Effects of 28-day nose-only inhalation of PCB52 (2,2',5,5'-Tetrachlorobiphenyl) on the brain transcriptome.Toxicology · 2024Article
- Interactions of Polychlorinated Biphenyls and Their Metabolites with the Brain and Liver Transcriptome of Female Mice.ACS chemical neuroscience · 2024Article
- Metabolic activation of WHO-congeners PCB28, 52, and 101 by human CYP2A6: evidence from in vitro and in vivo experiments.Archives of toxicology · 2024Article
- Upregulation of fatty acid synthesis genes in the livers of adolescent female rats caused by inhalation exposure to PCB52 (2,2',5,5'-Tetrachlorobiphenyl).Environmental toxicology and pharmacology · 2024Article
- Distribution of 2,2',5,5'-Tetrachlorobiphenyl (PCB52) Metabolites in Adolescent Rats after Acute Nose-Only Inhalation Exposure.Environmental science & technology · 2024Article
- Article
- Disposition and metabolomic effects of 2,2',5,5'-tetrachlorobiphenyl in female rats following intraperitoneal exposure.Environmental toxicology and pharmacology · 2023Article
- Disposition and Metabolomic Effects of 2,2',5,5'-Tetrachlorobiphenyl in Female Rats Following Intraperitoneal Exposure.bioRxiv : the preprint server for biology · 2023Article
- Hydroxylation markedly alters how the polychlorinated biphenyl (PCB) congener, PCB52, affects gene expression in human preadipocytes.Toxicology in vitro : an international journal published in association with BIBRA · 2023Article
- Probing the Role of CYP2 Enzymes in the Atropselective Metabolism of Polychlorinated Biphenyls Using Liver Microsomes from Transgenic Mouse Models.Chemical research in toxicology · 2022Article
- Assessment of Polychlorinated Biphenyls and Their Hydroxylated Metabolites in Postmortem Human Brain Samples: Age and Brain Region Differences.Environmental science & technology · 2022Article
- Characterization of the Metabolic Pathways of 4-Chlorobiphenyl (PCB3) in HepG2 Cells Using the Metabolite Profiles of Its Hydroxylated Metabolites.Environmental science & technology · 2021Article
- Review
- Human CYP2A6, CYP2B6, AND CYP2E1 Atropselectively Metabolize Polychlorinated Biphenyls to Hydroxylated Metabolites.Environmental science & technology · 2019Article
- Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone.Xenobiotica; the fate of foreign compounds in biological systems · 2019Article
- Dietary Flavonoids Interaction with CREB-BDNF Pathway: An Unconventional Approach for Comprehensive Management of Epilepsy.Current neuropharmacology · 2019Review
- Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs).Environmental science and pollution research international · 2018Article
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Authors and funding
10 authors at 1 institution in 3 countries.
Tsutomu ShimadaLaboratory of Cellular and Molecular Biology, Osaka Prefecture University, Izumisano, Osaka, Japan (T.S., S.T., M.K.); Osaka Prefectural Institute of Public Health, Higashinari-ku, Osaka, Japan (K.K.); Faculty of Nutritional Sciences, Nakamura Gakuen University, Johnan-ku, Fukuoka, Japan (N.K.); Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.U., N.M., H.Y.); Department of Biological Sciences, Konkuk University, Seoul, South Korea (D.K.); and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee (F.P.G.) t.shimada@vet.osakafu-u.ac.jp.
Kensaku KakimotoLaboratory of Cellular and Molecular Biology, Osaka Prefecture University, Izumisano, Osaka, Japan (T.S., S.T., M.K.); Osaka Prefectural Institute of Public Health, Higashinari-ku, Osaka, Japan (K.K.); Faculty of Nutritional Sciences, Nakamura Gakuen University, Johnan-ku, Fukuoka, Japan (N.K.); Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.U., N.M., H.Y.); Department of Biological Sciences, Konkuk University, Seoul, South Korea (D.K.); and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee (F.P.G.).
Shigeo TakenakaLaboratory of Cellular and Molecular Biology, Osaka Prefecture University, Izumisano, Osaka, Japan (T.S., S.T., M.K.); Osaka Prefectural Institute of Public Health, Higashinari-ku, Osaka, Japan (K.K.); Faculty of Nutritional Sciences, Nakamura Gakuen University, Johnan-ku, Fukuoka, Japan (N.K.); Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.U., N.M., H.Y.); Department of Biological Sciences, Konkuk University, Seoul, South Korea (D.K.); and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee (F.P.G.).
Nobuyuki KogaLaboratory of Cellular and Molecular Biology, Osaka Prefecture University, Izumisano, Osaka, Japan (T.S., S.T., M.K.); Osaka Prefectural Institute of Public Health, Higashinari-ku, Osaka, Japan (K.K.); Faculty of Nutritional Sciences, Nakamura Gakuen University, Johnan-ku, Fukuoka, Japan (N.K.); Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.U., N.M., H.Y.); Department of Biological Sciences, Konkuk University, Seoul, South Korea (D.K.); and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee (F.P.G.).
Shotaro UeharaLaboratory of Cellular and Molecular Biology, Osaka Prefecture University, Izumisano, Osaka, Japan (T.S., S.T., M.K.); Osaka Prefectural Institute of Public Health, Higashinari-ku, Osaka, Japan (K.K.); Faculty of Nutritional Sciences, Nakamura Gakuen University, Johnan-ku, Fukuoka, Japan (N.K.); Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.U., N.M., H.Y.); Department of Biological Sciences, Konkuk University, Seoul, South Korea (D.K.); and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee (F.P.G.).
Norie MurayamaLaboratory of Cellular and Molecular Biology, Osaka Prefecture University, Izumisano, Osaka, Japan (T.S., S.T., M.K.); Osaka Prefectural Institute of Public Health, Higashinari-ku, Osaka, Japan (K.K.); Faculty of Nutritional Sciences, Nakamura Gakuen University, Johnan-ku, Fukuoka, Japan (N.K.); Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.U., N.M., H.Y.); Department of Biological Sciences, Konkuk University, Seoul, South Korea (D.K.); and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee (F.P.G.).
Hiroshi YamazakiLaboratory of Cellular and Molecular Biology, Osaka Prefecture University, Izumisano, Osaka, Japan (T.S., S.T., M.K.); Osaka Prefectural Institute of Public Health, Higashinari-ku, Osaka, Japan (K.K.); Faculty of Nutritional Sciences, Nakamura Gakuen University, Johnan-ku, Fukuoka, Japan (N.K.); Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.U., N.M., H.Y.); Department of Biological Sciences, Konkuk University, Seoul, South Korea (D.K.); and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee (F.P.G.).ORCID 0000-0002-1068-4261
Donghak KimLaboratory of Cellular and Molecular Biology, Osaka Prefecture University, Izumisano, Osaka, Japan (T.S., S.T., M.K.); Osaka Prefectural Institute of Public Health, Higashinari-ku, Osaka, Japan (K.K.); Faculty of Nutritional Sciences, Nakamura Gakuen University, Johnan-ku, Fukuoka, Japan (N.K.); Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.U., N.M., H.Y.); Department of Biological Sciences, Konkuk University, Seoul, South Korea (D.K.); and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee (F.P.G.).
F Peter GuengerichLaboratory of Cellular and Molecular Biology, Osaka Prefecture University, Izumisano, Osaka, Japan (T.S., S.T., M.K.); Osaka Prefectural Institute of Public Health, Higashinari-ku, Osaka, Japan (K.K.); Faculty of Nutritional Sciences, Nakamura Gakuen University, Johnan-ku, Fukuoka, Japan (N.K.); Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.U., N.M., H.Y.); Department of Biological Sciences, Konkuk University, Seoul, South Korea (D.K.); and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee (F.P.G.).
Masayuki KomoriLaboratory of Cellular and Molecular Biology, Osaka Prefecture University, Izumisano, Osaka, Japan (T.S., S.T., M.K.); Osaka Prefectural Institute of Public Health, Higashinari-ku, Osaka, Japan (K.K.); Faculty of Nutritional Sciences, Nakamura Gakuen University, Johnan-ku, Fukuoka, Japan (N.K.); Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.U., N.M., H.Y.); Department of Biological Sciences, Konkuk University, Seoul, South Korea (D.K.); and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee (F.P.G.).
Osaka Prefecture University · JP
Funding
Metabolism of Carcinogens and Drugs by Human P450sR01GM118122 · NIGMS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 2016 to 2023
$3.3MNIGMS NIH HHS R01 GM118122
Abstract
2,5,2',5'-Tetrachlorobiphenyl (TCB) induced type I binding spectra with cytochrome P450 (P450) 2A6 and 2A13, with K
Indexed as
AnimalsCatalysisCatalytic DomainCytochrome P-450 CYP2A6Cytochrome P-450 Enzyme SystemHaplorhiniHumansLigandsMolecular Docking SimulationOxidation-ReductionPolychlorinated BiphenylsProtein Binding2,5,2',5'-tetrachlorobiphenylCYP2A6 protein, humanCytochrome P-450 CYP2A6Cytochrome P-450 Enzyme SystemLigandsPolychlorinated Biphenyls
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