Evidence map›Paper›PMID 27625073›Full record

ArticleCell cycle (Georgetown, Tex.)2016

Kar9 controls the nucleocytoplasmic distribution of yeast EB1.

Jörg Schweiggert, Davide Panigada, Ann Na Tan, Dimitris Liakopoulos

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Jörg Schweiggerta Centre de Recherche en Biologie cellulaire de Montpellier (CRBM), CNRS UMR 523 , Montpellier , France.
Davide Panigadaa Centre de Recherche en Biologie cellulaire de Montpellier (CRBM), CNRS UMR 523 , Montpellier , France.
Ann Na Tanb Biochemistry Centre Heidelberg (BZH) , Heidelberg , Germany.
Dimitris Liakopoulosa Centre de Recherche en Biologie cellulaire de Montpellier (CRBM), CNRS UMR 523 , Montpellier , France.
Centre de Recherche en Biologie cellulaire de Montpellier · FRCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The precise temporal and spatial concentration of microtubule-associated proteins (MAPs) within the cell is fundamental to ensure chromosome segregation and correct spindle positioning. MAPs form an intricate web of interactions among each other and compete for binding sites on microtubules. Therefore, when assessing cellular phenotypes upon MAP up- or downregulation, it is important to consider the protein interaction network between individual MAPs. Here, we show that changes in the amounts of the spindle positioning factor Kar9 specifically affect the distribution of yeast EB1 on spindle microtubules, without influencing other microtubule-associated interacting partners of Kar9, i.e. yeast XMAP215 and CLIP-170. Alterations in the distribution of yeast EB1 explain chromosome segregation defects upon knockout, overexpression or stabilization of Kar9 and provide an example for non-linear effects on MAP behavior after perturbation of their equilibrium.

Indexed as

Cell NucleusChromosome SegregationGene Knockout TechniquesModels, BiologicalNuclear ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsKAR9 protein, S cerevisiaeNuclear ProteinsSaccharomyces cerevisiae Proteinschromosome segregationEB1Kar9spindle positioning

Identifiers

PMID27625073
PMCPMC5105927
OpenAlexW2519016208

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.