Evidence map›Paper›PMID 27624938›Full record

ArticleThe Journal of biological chemistry2016

Calcium Signaling Is Dispensable for Receptor Regulation of Endothelial Barrier Function.

Judith A Stolwijk, Xuexin Zhang, Maxime Gueguinou, Wei Zhang, Khalid Matrougui, Christian Renken, Mohamed Trebak

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Article
  3. bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Molecular Mechanisms Regulating Vascular Endothelial Permeability.International journal of molecular sciences · 2024
    Review
  6. Modulation of the Blood-Brain Barrier by Sigma-1R Activation.International journal of molecular sciences · 2024
    Article
  7. The Molecular Heterogeneity of Store-Operated CaInternational journal of molecular sciences · 2023
    Review
  8. Review
  9. Small-world connectivity dictates collective endothelial cell signaling.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Role of store-operated Ca2+ entry in cardiovascular disease.Cell communication and signaling : CCS · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Noncanonical function of long myosin light chain kinase in increasing ER-PM junctions and augmentation of SOCE.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  15. Review
  16. Review
  17. Article
  18. ZIPK mediates endothelial cell contraction through myosin light chain phosphorylation and is required for ischemic-reperfusion injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Judith A StolwijkFrom the Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033.
Xuexin ZhangFrom the Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033.
Maxime GueguinouFrom the Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033.
Wei ZhangFrom the Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033.
Khalid Matrouguithe Department of Physiological Sciences, East Virginia Medical School, Norfolk, Virginia 23507, and.
Christian Renkenthe Applied Biophysics Inc., Troy, New York 12180.
Mohamed TrebakFrom the Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, mtrebak@hmc.psu.edu.
Pennsylvania State University · USApplied BioPhysics (United States) · USEastern Virginia Medical School · US

Funding

Receptor-regulated Ca2+ Entry Pathways in Smooth MuscleR01HL097111 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2010 to 2019
$3.7M
Mechanisms of Coronary Arteriolar Dysfunction in Type 2 DiabetesR01HL095566 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI MATROUGUI, KHALID · 2010 to 2014
$1.8M
Leukotriene C4 and STIM/Orai channels in airway smooth muscle remodelingR01HL123364 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2014 to 2017
$1.5M
NHLBI NIH HHS R01 HL095566NHLBI NIH HHS R01 HL097111NHLBI NIH HHS R01 HL123364
6 · The paper itself

Abstract

Endothelial barrier function is tightly regulated by plasma membrane receptors and is crucial for tissue fluid homeostasis; its dysfunction causes disease, including sepsis and inflammation. The ubiquitous activation of Ca

Indexed as

Calcium SignalingCalciumCell MembraneCells, CulturedEndothelial CellsHumansLysophospholipidsNeoplasm ProteinsORAI1 ProteinSphingosineStromal Interaction Molecule 1ThrombinCalciumLysophospholipidsNeoplasm ProteinsORAI1 ProteinSphingosinesphingosine 1-phosphateSTIM1 protein, humanStromal Interaction Molecule 1Thrombincalcium release-activated calcium channel protein 1 (ORAI1)calcium signalingendothelial cellendothelial dysfunctionG protein-coupled receptor (GPCR)stromal interaction molecule 1 (STIM1)

Identifiers

PMID27624938
PMCPMC5087712
OpenAlexW2520804110

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.