ArticleThe Plant cell2016
The Arabidopsis sickle Mutant Exhibits Altered Circadian Clock Responses to Cool Temperatures and Temperature-Dependent Alternative Splicing.
Article in The Plant cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 63 citations in OpenAlex.
- MAC5A dual-functionally regulates cold responses at both transcriptional and post-transcriptional levels.Journal of advanced research · 2026Article
- XAP5 CIRCADIAN TIMEKEEPER coordinates circadian rhythms and anthocyanin biosynthesis independently of splicing.Plant physiology · 2026Article
- Temperature compensation of the Arabidopsis circadian clock.Npj biological timing and sleep · 2025Review
- A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Integrating temperature into the Arabidopsis circadian system.Npj biological timing and sleep · 2025Review
- Alternative splicing ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Sequestration of DBR1 to stress granules promotes lariat intronic RNAs accumulation for heat-stress tolerance.Nature communications · 2024Article
- Alternative splicing ofbioRxiv : the preprint server for biology · 2024Article
- A Luciferase Imaging-Based Assay for Studying Temperature Compensation of the Circadian Clock.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Myb-like transcription factors have epistatic effects on circadian clock function but additive effects on plant growth.Plant direct · 2023Article
- Genome and whole-genome resequencing of Cinnamomum camphora elucidate its dominance in subtropical urban landscapes.BMC biology · 2023Article
- sic-4 Reports in sick! Loss of SICKLE induces salicylic acid-dependent cell death in Arabidopsis.Plant physiology · 2023Article
- XAP5 CIRCADIAN TIMEKEEPER regulates RNA splicing and the circadian clock by genetically separable pathways.Plant physiology · 2023Article
- Absence of SICKLE triggers programed cell death by disturbing alternative splicing and decay of mRNAs.Plant physiology · 2023Article
- Variations in Circadian Clock Organization & Function: A Journey from Ancient to Recent.Planta · 2022Review
- Circadian entrainment in Arabidopsis.Plant physiology · 2022Article
- SICKLE modulates lateral root development by promoting degradation of lariat intronic RNA.Plant physiology · 2022Article
- Impact of the sickle mutant and temperature on the structure of transcripts and RNAs from Arabidopsis thaliana.BMC research notes · 2022Article
- The Roles of Temperature-Related Post-Transcriptional Regulation in Cereal Floral Development.Plants (Basel, Switzerland) · 2021Review
- Daily temperature cycles promote alternative splicing of RNAs encoding SR45a, a splicing regulator in maize.Plant physiology · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The circadian clock allows plants to anticipate and respond to daily changes in ambient temperature. Mechanisms establishing the timing of circadian rhythms in Arabidopsis thaliana through temperature entrainment remain unclear. Also incompletely understood is the temperature compensation mechanism that maintains consistent period length within a range of ambient temperatures. A genetic screen for Arabidopsis mutants affecting temperature regulation of the PSEUDO-RESPONSE REGULATOR7 promoter yielded a novel allele of the SICKLE (SIC) gene. This mutant, sic-3, and the existing sic-1 mutant both exhibit low-amplitude or arrhythmic expression of core circadian clock genes under cool ambient temperature cycles, but not under light-dark entrainment. sic mutants also lengthen free running period in a manner consistent with impaired temperature compensation. sic mutant alleles accumulate LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK ASSOCIATED1 (CCA1) splice variants, among other alternatively spliced transcripts, which is exacerbated by cool temperatures. The cca1-1 lhy-20 double mutant is epistatic to sic-3, indicating the LHY and CCA1 splice variants are needed for sic-3 circadian clock phenotypes. It is not expected that SIC is directly involved in the circadian clock mechanism; instead, SIC likely contributes to pre-mRNA metabolism, and the splice variants that accumulate in sic mutants likely affect the circadian clock response to cool ambient temperature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.