Evidence map›Paper›PMID 27624659›Full record

ArticleAnnals of biomedical engineering2017

Fluid-Structure Interaction Analysis of Ruptured Mitral Chordae Tendineae.

Milan Toma, Charles H Bloodworth, Eric L Pierce, Daniel R Einstein, Richard P Cochran, Ajit P Yoganathan, Karyn S Kunzelman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Clinical Impact of Computational Heart Valve Models.Materials (Basel, Switzerland) · 2022
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Analysis of a coupled fluid-structure interaction model of the left atrium and mitral valve.International journal for numerical methods in biomedical engineering · 2019
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Milan TomaWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Technology Enterprise Park, Suite 200, 387 Technology Circle, Atlanta, GA, 30313-2412, USA.
Charles H BloodworthWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Technology Enterprise Park, Suite 200, 387 Technology Circle, Atlanta, GA, 30313-2412, USA.
Eric L PierceWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Technology Enterprise Park, Suite 200, 387 Technology Circle, Atlanta, GA, 30313-2412, USA.
Daniel R EinsteinDepartment of Mechanical Engineering, St. Martin's University, 5000 Abbey Way SE, Lacey, WA, 98503, USA.
Richard P CochranDepartment of Mechanical Engineering, University of Maine, 219 Boardman Hall, Orono, ME, 04469-5711, USA.
Ajit P YoganathanWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Technology Enterprise Park, Suite 200, 387 Technology Circle, Atlanta, GA, 30313-2412, USA. ajit.yoganathan@bme.gatech.edu.
Karyn S KunzelmanDepartment of Mechanical Engineering, University of Maine, 219 Boardman Hall, Orono, ME, 04469-5711, USA.

Funding

Percutaneous Mitral Valve Repair: A Validated Fluid-Structure Interaction ModelR01HL092926 · NHLBI · UNIVERSITY OF MAINE ORONO · PI KUNZELMAN, KARYN S · 2009 to 2013
$2.9M
NHLBI NIH HHS R01 HL092926
6 · The paper itself

Abstract

The chordal structure is a part of mitral valve geometry that has been commonly neglected or simplified in computational modeling due to its complexity. However, these simplifications cannot be used when investigating the roles of individual chordae tendineae in mitral valve closure. For the first time, advancements in imaging, computational techniques, and hardware technology make it possible to create models of the mitral valve without simplifications to its complex geometry, and to quickly run validated computer simulations that more realistically capture its function. Such simulations can then be used for a detailed analysis of chordae-related diseases. In this work, a comprehensive model of a subject-specific mitral valve with detailed chordal structure is used to analyze the distinct role played by individual chordae in closure of the mitral valve leaflets. Mitral closure was simulated for 51 possible chordal rupture points. Resultant regurgitant orifice area and strain change in the chordae at the papillary muscle tips were then calculated to examine the role of each ruptured chorda in the mitral valve closure. For certain subclassifications of chordae, regurgitant orifice area was found to trend positively with ruptured chordal diameter, and strain changes correlated negatively with regurgitant orifice area. Further advancements in clinical imaging modalities, coupled with the next generation of computational techniques will enable more physiologically realistic simulations.

Indexed as

HemodynamicsMitral ValveModels, CardiovascularAnimalsRupture, SpontaneousSheepChordae tendineaeChordal ruptureComprehensive modelComputer simulationFluid-structure interactionMitral valve

Identifiers

PMID27624659
PMCPMC5332285

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.