Evidence map›Paper›PMID 27624619›Full record

ArticleJournal of cell communication and signaling2016

An overview of the oxytocin-oxytocin receptor signaling network.

Oishi Chatterjee, Krutika Patil, Apeksha Sahu, Lathika Gopalakrishnan, Praseeda Mol, Jayshree Advani, Srabani Mukherjee, Rita Christopher, T S Keshava Prasad

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell communication and signaling, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Novel Risk Variants in the Oxytocin Receptor Gene (International journal of molecular sciences · 2023
    Article
  7. Article
  8. A molecular network map of orexin-orexin receptor signaling system.Journal of cell communication and signaling · 2023
    Article
  9. Article
  10. Review
  11. Review
  12. Opioid receptors signaling network.Journal of cell communication and signaling · 2022
    Article
  13. Review
  14. The combined use of acetazolamide andAnnals of translational medicine · 2022
    Article
  15. Article
  16. An assembly of galanin-galanin receptor signaling network.Journal of cell communication and signaling · 2021
    Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Oishi ChatterjeeInternational Technology Park, Institute of Bioinformatics, Bangalore, 560066, India.
Krutika PatilMolecular Endocrinology, National Institute for Research in Reproductive Health, Parel, Mumbai, 400012, India.
Apeksha SahuInternational Technology Park, Institute of Bioinformatics, Bangalore, 560066, India.
Lathika GopalakrishnanInternational Technology Park, Institute of Bioinformatics, Bangalore, 560066, India.
Praseeda MolInternational Technology Park, Institute of Bioinformatics, Bangalore, 560066, India.
Jayshree AdvaniInternational Technology Park, Institute of Bioinformatics, Bangalore, 560066, India.
Srabani MukherjeeMolecular Endocrinology, National Institute for Research in Reproductive Health, Parel, Mumbai, 400012, India.
Rita ChristopherDepartment of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore, 560029, India.
T S Keshava PrasadInternational Technology Park, Institute of Bioinformatics, Bangalore, 560066, India. keshav@ibioinformatics.org.
Institute of Bioinformatics · INNational Institute for Research in Reproductive Health · INManipal Academy of Higher Education · INNational Institute of Mental Health and Neurosciences · INPondicherry University · INYenepoya University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxytocin, a nine amino acid long neuropeptide hormone, is synthesized in the hypothalamus and stored and released from the neural lobe of the pituitary gland. Although commonly known for its central role in the regulation of parturition and lactation, oxytocin signaling also plays a key role in modulating social behavior, evoking contentment, initiating maternal behavior, inducing trust, generosity and bonding in humans and animals. Oxytocin signaling can prove to be of great importance in therapeutics and drug targeting because of its diverse range of actions. However, a well annotated map of oxytocin signaling pathway is currently lacking in the publicly available pathway resources. Therefore, we systematically curated the available signaling information of oxytocin from published literature and collated the data to develop a more complete map. We cataloged 66 molecules belonging to oxytocin signaling pathway, which included 9 protein-protein interactions, 39 post-translational modifications, 14 protein translocation events and 22 activation/inhibition events. Further, Oxytocin signaling network data is made freely available to academic fraternity by integrating this into NetPath ( http://www.netpath.org /), a freely available human signaling pathway resource developed previously by our group.

Indexed as

Gene expressionG-protein coupled receptorHerring bodiesNociceptionOsteoclastogenesisProstaglandins

Identifiers

PMID27624619
PMCPMC5143325
OpenAlexW2519924201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.