Trial reportJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2016
Assessment of Diastolic Function in Single-Ventricle Patients After the Fontan Procedure.
Trial report in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The trial behind it
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Who cites it
21 citing papers in PubMed.
- Impact of Udenafil on Echocardiographic Indices of Single Ventricle Size and Function in FUEL Study Participants.Circulation. Cardiovascular imaging · 2022Trial
- Reduced atrial conduit strain and abnormal diastolic filling are associated with fontan-associated liver disease.The international journal of cardiovascular imaging · 2026Article
- Natural Shear Wave Elastography: A Promising Tool to Assess Myocardial Stiffness in Fontan Patients.JACC. Advances · 2026Article
- Accuracy and reliability of non-invasive pressure-strain loop for myocardial work assessment in functional single ventricle patients.BMC cardiovascular disorders · 2025Article
- Reduced myocardial work in Fontan circulation: feasibility, reproducibility, and diagnostic performance.European heart journal. Imaging methods and practice · 2025Article
- Heart-Liver Interplay in Patients with Fontan Circulation.Journal of clinical medicine · 2025Article
- How cardiac output is controlled in a Fontan circulation: an update.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Echocardiographic Strain to Predict Need for Transplant or Mortality in Fontan Patients with Hypoplastic Left Heart Syndrome.Pediatric cardiology · 2024Article
- Optimal Heart Rate May Improve Systolic and Diastolic Function in Patients with Fontan Circulation.Journal of clinical medicine · 2023Article
- Occult Diastolic Dysfunction and Adverse Clinical Outcomes in Adolescents and Young Adults With Fontan Circulation.Journal of the American Heart Association · 2023Observational
- A practical guideline for performing a comprehensive transthoracic echocardiogram in the congenital heart disease patient: consensus recommendations from the British Society of Echocardiography.Echo research and practice · 2022Review
- Therapeutic Approaches in Heart Failure with Preserved Ejection Fraction (HFpEF) in Children: Present and Future.Paediatric drugs · 2022Review
- Diastolic Dysfunction With Preserved Ejection Fraction After the Fontan Procedure.Journal of the American Heart Association · 2022Article
- Cardiac Imaging in Patients After Fontan Palliation: Which Test and When?Frontiers in pediatrics · 2022Review
- Management of circulatory failure after Fontan surgery.Frontiers in pediatrics · 2022Review
- Reaching consensus for unified medical language in Fontan care.ESC heart failure · 2021Article
- Assessing Single Ventricle Function in the Fontan Circulation using Wave Intensity Analysis.Pediatric cardiology · 2021Article
- Dobutamine stress testing for the evaluation of atrial and diastolic ventricular function in Fontan patients.Open heart · 2021Article
- Flow profile characteristics in Fontan circulation are associated with the single ventricle dilation and function: principal component analysis study.American journal of physiology. Heart and circulatory physiology · 2020Article
- Providing a framework of principles for conceptualising the Fontan circulation.Acta paediatrica (Oslo, Norway : 1992) · 2020Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundPatients with functional single ventricles after the Fontan procedure have abnormal cardiac mechanics. The aims of this study were to determine factors that influence diastolic function and to describe associations of diastolic function with current clinical status.
methodsEchocardiograms were obtained as part of the Pediatric Heart Network Fontan Cross-Sectional Study. Diastolic function grade (DFG) was assessed as normal (grade 0), impaired relaxation (grade 1), pseudonymization (grade 2), or restrictive (grade 3). Studies were also classified dichotomously (restrictive pattern present or absent). Relationships between DFG and pre-Fontan variables (e.g., ventricular morphology, age at Fontan, history of volume-unloading surgery) and current status (e.g., systolic function, valvar regurgitation, exercise performance) were explored.
resultsDFG was calculable in 326 of 546 subjects (60%) (mean age, 11.7 ± 3.3 years). Overall, 32% of patients had grade 0, 9% grade 1, 37% grade 2, and 22% grade 3 diastolic function. Although there was no association between ventricular morphology and DFG, there was an association between ventricular morphology and E', which was lowest in those with right ventricular morphology (P < .001); this association remained significant when using Z scores adjusted for age (P < .001). DFG was associated with achieving maximal effort on exercise testing (P = .004); the majority (64%) of those not achieving maximal effort had DFG 2 or 3. No additional significant associations of DFG with laboratory or clinical measures were identified.
conclusionsAssessment of diastolic function by current algorithms results in a high percentage of patients with abnormal DFG, but few clinically or statistically significant associations were found. This may imply a lack of impact of abnormal diastolic function on clinical outcomes in this cohort, or it may indicate that the methodology may not be applicable to pediatric patients with functional single ventricles.
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