Evidence map›Paper›PMID 27624516›Full record

ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2016

A novel, validated risk score to predict surgical site infection after pancreaticoduodenectomy.

Katherine E Poruk, Joseph A Lin, Michol A Cooper, Jin He, Martin A Makary, Kenzo Hirose, John L Cameron, Timothy M Pawlik, Christopher L Wolfgang, Frederic Eckhauser and 1 more

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  12. Severity of Pancreatic Leak in Relation to Gut Restoration After Pancreaticoduodenectomy: The Role of the Roux-en-Y Configuration.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Katherine E PorukDepartment of Surgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Joseph A LinDepartment of Surgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Michol A CooperDepartment of Surgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Jin HeDepartment of Surgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Martin A MakaryDepartment of Surgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Kenzo HiroseDepartment of Surgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.
John L CameronDepartment of Surgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Timothy M PawlikDepartment of Surgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Christopher L WolfgangDepartment of Surgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Frederic EckhauserDepartment of Surgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Matthew J WeissDepartment of Surgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA. Electronic address: mweiss5@jhmi.edu.

Funding

Clinical and Laboratory Research Training for Surgical OncologistsT32CA126607 · NCI · JOHNS HOPKINS UNIVERSITY · PI CAMERON, ANDREW M. · 2008 to 2024
$6.0M
NCI NIH HHS CA126607-06A1
6 · The paper itself

Abstract

backgroundAlthough pancreaticoduodenectomy (PD) outcomes have improved, complications including surgical site infection (SSI) remain common. We present a stratification tool to predict risk for SSI after PD.

methodsData was retrospectively reviewed on all patients undergoing PD at a tertiary hospital (9/2011-8/2014). Potential SSI risk factors identified by univariate analysis were incorporated into a multivariate logistic regression model. The resulting odds ratios were converted into a point system to create an SSI risk score with internal validation.

resultsSix hundred seventy nine patients underwent PD and were chronologically split into derivation (443 patients) and validation (236 patients) groups. There was no difference in demographics or perioperative outcomes between groups. Overall thirty-day SSI was observed in 17.2% (n = 117). Neoadjuvant chemotherapy and/or radiation, intraoperative red blood cell transfusion, operative time greater than 7 h, preoperative bile stent/drain, and vascular resection were associated with SSI in univariate analysis (all p < 0.05). On multivariate analysis, preoperative bile stent/drain and neoadjuvant chemotherapy were independent predictors of SSI, each assigned 1 point (both p < 0.001). Patients with 0, 1, and 2 points, respectively, had 0%, 32%, and 64% predicted risk of SSI (AUC = 0.73, R

conclusionThis novel, validated risk score accurately predicts SSI risk after pancreaticoduodenectomy. Identifying the highest risk patients can help target interventions to reduce SSI.

Indexed as

Decision Support TechniquesAdultAgedAged, 80 and overCarcinoma, Pancreatic DuctalChemotherapy, AdjuvantDrainageFemaleHumansLinear ModelsLogistic ModelsMaleMiddle AgedMultivariate AnalysisNegative-Pressure Wound TherapyNeoadjuvant Therapy

Identifiers

PMID27624516
PMCPMC5094482

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.