Evidence map›Paper›PMID 27624464›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2017

2016 updated MASCC/ESMO consensus recommendations: prevention of radiotherapy-induced nausea and vomiting.

Christina H Ruhlmann, Franziska Jahn, Karin Jordan, Kristopher Dennis, Ernesto Maranzano, Alexander Molassiotis, Fausto Roila, Petra Feyer

Abstract readSystematic ReviewConsensus Statement
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. 2023 Updated MASCC/ESMO Consensus Recommendations: prevention of radiotherapy- and chemoradiotherapy-induced nausea and vomiting.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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  13. SEOM Clinical Guideline update for the prevention of chemotherapy-induced nausea and vomiting (2016).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 5 countries.

Christina H RuhlmannDepartment of Oncology, Odense University Hospital, Sdr. Boulevard 29, DK-5000, Odense C, Denmark. c.ruhlmann@dadlnet.dk.
Franziska JahnDepartment of Hematology and Oncology, Martin-Luther University Halle-Wittenberg, Halle, Germany University of Halle, Ernst Grube Strasse 40, Halle, Germany.
Karin JordanDepartment of Hematology and Oncology, Martin-Luther University Halle-Wittenberg, Halle, Germany University of Halle, Ernst Grube Strasse 40, Halle, Germany.
Kristopher DennisDivision of Radiation Oncology, Ottawa Hospital Research Institute, University of Ottawa, 501 Smyth Road, Ottawa, Ontario, K1H8L6, Canada.
Ernesto MaranzanoDepartement of Oncology, Radiation Oncology Centre, Azienda Ospedaliera S. Maria, Via T. di Joannuccio 1, 05100, Terni, Italy.
Alexander MolassiotisSchool of Nursing, The Hong Kong Polytechnic University, 11 Yuk Choi Rd, Hung Hom, Hong Kong, China.
Fausto RoilaDepartement of Oncology, Medical Oncology Division, Azienda Ospedaliera S. Maria, Via T. di Joannuccio 1, 05100, Terni, Italy.
Petra FeyerDepartment of Radiation Oncology, Vivantes Clinics Neukoelln, Rudower Str. 48, 12351, Berlin, Germany.
Azienda Ospedaliera S.Maria · ITMartin Luther University Halle-Wittenberg · DEHong Kong Polytechnic University · HKOdense University Hospital · DKOttawa Hospital · CAVivantes Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRadiotherapy-induced nausea and vomiting (RINV) are distressing symptoms. Evidence-based guidelines should facilitate the prescription of the best possible antiemetic prophylaxis. As part of the MASCC/ESMO Antiemetic Guidelines Update 2016, a thorough review of the literature concerning RINV since the 2009 update was required.

methodsA systematic review of the literature including data published from June 2009 to May 2015 was performed. Committee VII (RINV) under the MASCC/ESMO Antiemetic Guidelines Update Committee assessed the literature.

resultsThe searches yielded 926 records, 906 records were excluded, leaving 20 records for full text assessment, and 18 publications were finally included. The only fully published randomized studies in prevention of RINV were two negative studies in acupuncture and green tea, respectively. No data to support new recommendations for antiemetic prophylaxis in RINV was available. However, based on expert opinions, the committee agreed on changes in emetic risk level for certain sites of irradiation.

conclusionsThe serotonin receptor antagonists are still the corner stone in antiemetic prophylaxis of nausea and vomiting induced by high and moderate emetic risk radiotherapy. The studies available since the last update did not change recommendations for antiemetic prophylaxis. The emetogenicity of craniospinal radiotherapy was reclassified from low to moderate emetic level along with some other minor changes. In the future, RINV prophylaxis in single fraction, multiple fraction, and in concomitant chemo-radiotherapy still need to be explored with regard to the different classes and combinations of antiemetic drugs.

Indexed as

AntiemeticsHumansNauseaPractice Guidelines as TopicRadiation InjuriesRadiotherapyRandomized Controlled Trials as TopicRiskVomitingAntiemeticsAntiemeticsGuidelineNauseaRadiotherapyVomiting

Identifiers

PMID27624464
OpenAlexW2520294812

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.