ArticleScientific reports2016
Mechanistic Modelling of DNA Repair and Cellular Survival Following Radiation-Induced DNA Damage.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- A polymer physics model of the interphase cell nucleus for radiobiological simulations.Scientific reports · 2026Article
- An overlooked source of skin dose perturbation: Commercial tattoo inks in radiotherapy.PloS one · 2026Article
- Assessing the Relative Contribution of DSB Repair Proteins as a Function of LET.International journal of particle therapy · 2025Article
- The temporal response of a glioma cell population to irradiation: modelling the effect of dose and cell density.Royal Society open science · 2025Article
- AMBER: A Modular Model for Tumor Growth, Vasculature and Radiation Response.Bulletin of mathematical biology · 2024Article
- Effects of Differing Underlying Assumptions in In Silico Models on Predictions of DNA Damage and Repair.Radiation research · 2023Article
- Estimation of relative biological effectiveness ofEJNMMI physics · 2023Article
- A systematic analysis of the particle irradiation data ensemble in the key of the microdosimetric kinetic model: Should clonogenic data be used for clinical relative biological effectiveness?Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2023Article
- High-LET radiation induces large amounts of rapidly-repaired sublethal damage.Scientific reports · 2023Article
- Dependence of Induced Biological Damage on the Energy Distribution and Intensity of Clinical Intra-Operative Radiotherapy Electron Beams.International journal of molecular sciences · 2023Article
- Initial yield of hydrated electron production from water radiolysis based on first-principles calculation.RSC advances · 2023Article
- Prediction of DNA rejoining kinetics and cell survival after proton irradiation for V79 cells using Geant4-DNA.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2023Article
- The Mayo Clinic Florida Microdosimetric Kinetic Model of Clonogenic Survival: Application to Various Repair-Competent Rodent and Human Cell Lines.International journal of molecular sciences · 2022Article
- Computational modelling of γ-H2AX foci formation in human cells induced by alpha particle exposure.Scientific reports · 2022Article
- A computational approach to quantifying miscounting of radiation-induced double-strand break immunofluorescent foci.Communications biology · 2022Article
- AOP report: Development of an adverse outcome pathway for oxidative DNA damage leading to mutations and chromosomal aberrations.Environmental and molecular mutagenesis · 2022Article
- Track Structure Components: Characterizing Energy Deposited in Spherical Cells from Direct and Peripheral HZE Ion Hits.Life (Basel, Switzerland) · 2021Article
- The relation between microdosimetry and induction of direct damage to DNA by alpha particles.Physics in medicine and biology · 2021Article
- Multi-scaled Monte Carlo calculation for radon-induced cellular damage in the bronchial airway epithelium.Scientific reports · 2021Article
- Total Body Irradiation for Hematopoietic Stem Cell Transplantation: What Can We Agree on?Current oncology (Toronto, Ont.) · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Characterising and predicting the effects of ionising radiation on cells remains challenging, with the lack of robust models of the underlying mechanism of radiation responses providing a significant limitation to the development of personalised radiotherapy. In this paper we present a mechanistic model of cellular response to radiation that incorporates the kinetics of different DNA repair processes, the spatial distribution of double strand breaks and the resulting probability and severity of misrepair. This model enables predictions to be made of a range of key biological endpoints (DNA repair kinetics, chromosome aberration and mutation formation, survival) across a range of cell types based on a set of 11 mechanistic fitting parameters that are common across all cells. Applying this model to cellular survival showed its capacity to stratify the radiosensitivity of cells based on aspects of their phenotype and experimental conditions such as cell cycle phase and plating delay (correlation between modelled and observed Mean Inactivation Doses R(2) > 0.9). By explicitly incorporating underlying mechanistic factors, this model can integrate knowledge from a wide range of biological studies to provide robust predictions and may act as a foundation for future calculations of individualised radiosensitivity.
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