Evidence map›Paper›PMID 27624437›Full record

ArticleScientific reports2016

Deep brain stimulation of the subthalamic nucleus modulates sensitivity to decision outcome value in Parkinson's disease.

Ben Seymour, Michael Barbe, Peter Dayan, Tamara Shiner, Ray Dolan, Gereon R Fink

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04650932 (Dual Frequency, Dual Region Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04650932 narecruitingnot on this mapstarted 2022, after this paper: background citation

Dual Frequency, Dual Region Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease

TypeinterventionalSponsorUniversity of California, DavisRan2022 to 2026Enrolled10ConditionsParkinson DiseaseArmsDeep brain stimulation
3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Trial
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  6. Review
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  8. Mice exhibit stochastic and efficient action switching during probabilistic decision making.Proceedings of the National Academy of Sciences of the United States of America · 2022
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  10. Review
  11. Observational
  12. Article
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ben SeymourComputational and Biological Learning Lab, Department of Engineering, University of Cambridge, UK.
Michael BarbeDepartment of Neurology, University Hospital, Cologne, Germany.
Peter DayanGatsby Computational Neuroscience Unit, UCL, London, UK.
Tamara ShinerWellcome Trust Centre for Neuroimaging, UCL, London, UK.
Ray DolanWellcome Trust Centre for Neuroimaging, UCL, London, UK.
Gereon R FinkDepartment of Neurology, University Hospital, Cologne, Germany.

Funding

Wellcome Trust 091593Wellcome Trust 098362
6 · The paper itself

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus in Parkinson's disease is known to cause a subtle but important adverse impact on behaviour, with impulsivity its most widely reported manifestation. However, precisely which computational components of the decision process are modulated is not fully understood. Here we probe a number of distinct subprocesses, including temporal discount, outcome utility, instrumental learning rate, instrumental outcome sensitivity, reward-loss trade-offs, and perseveration. We tested 22 Parkinson's Disease patients both on and off subthalamic nucleus deep brain stimulation (STN-DBS), while they performed an instrumental learning task involving financial rewards and losses, and an inter-temporal choice task for financial rewards. We found that instrumental learning performance was significantly worse following stimulation, due to modulation of instrumental outcome sensitivity. Specifically, patients became less sensitive to decision values for both rewards and losses, but without any change to the learning rate or reward-loss trade-offs. However, we found no evidence that DBS modulated different components of temporal impulsivity. In conclusion, our results implicate the subthalamic nucleus in a modulation of outcome value in experience-based learning and decision-making in Parkinson's disease, suggesting a more pervasive role of the subthalamic nucleus in the control of human decision-making than previously thought.

Indexed as

AgedChoice BehaviorCognitionDecision MakingDeep Brain StimulationFemaleHumansImpulsive BehaviorLearningMaleMiddle AgedNeuropsychological TestsParkinson DiseaseRewardSubthalamic Nucleus

Identifiers

PMID27624437
PMCPMC5021944

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.