ArticleInteractive cardiovascular and thoracic surgery2017
The extracellular matrix patch implanted in the right ventricle evaluated with cardiovascular magnetic resonance protocol to assess regional physio-mechanical properties.
Article in Interactive cardiovascular and thoracic surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.
- Strain-encoded magnetic resonance: a method for the assessment of myocardial deformation.ESC heart failure · 2019Pooled it
- Impact of formalin fixation on biventricular parameters in cardiac diffusion tensor imaging: A pilot study in a miniature swine model.The international journal of cardiovascular imaging · 2026Article
- Late Gadolinium Enhancement in Repaired Tetralogy of Fallot May Overestimate Right Ventricular Myocardial Fibrosis.Pediatric cardiology · 2026Article
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4 authors at 1 institution in 1 country.
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Abstract
objectivesAn extracellular matrix patch was implanted in the porcine right ventricle for in situ myocardial regeneration. A newly developed cardiovascular magnetic resonance protocol was utilized to investigate the regional physio-mechanical function of the patch.
methodsCardiovascular magnetic resonance was performed at 60-day after the porcine right ventricular wall full thickness substitution with an extracellular matrix cardiac patch (n = 5). Dacron patches and remote normal right ventricle served as control (n = 5/each). Late gadolinium enhancement, strain encoding and rest perfusion were measured for scar/patch detection, regional contractility and tissue perfusion. Image analyses were performed by two observers to validate interobserver reproducibility.
resultsAll imaging sequences were successfully obtained. The patches were located with late gadolinium enhancement imaging in 95% accuracy. All the parameters demonstrated significant differences among extracellular matrix, Dacron and normal myocardium (P < 0.05), which correlated with histological findings, including constructive remodelling with nascent myocardium and profound vasculogenesis/angiogenesis in extracellular matrix patches, and scar formation in Dacron. Bland-Altman analysis demonstrated good interobserver reproducibility with minimal bias (strain encoding/peak strain: mean difference = -0.32%, 95% limits of agreement = -1.2 to 0.57, correlation = 0.97; rest perfusion/relative maximum upslope: mean difference = -0.74, 95% limits of agreement = -2.0 to 0.53, correlation = 0.92), along with excellent correlation obtained from linear regression (strain encoding: R
conclusionsWith the cardiovascular magnetic resonance protocol, we successfully confirmed early signs of functional myocardial regeneration in implanted extracellular matrix patches. This approach is promising in assessing in situ regional physio-mechanical properties and degree of regeneration of implanted tissue-engineered materials.
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