Evidence map›Paper›PMID 27624297›Full record

ReviewJournal of endocrinological investigation2017

The treatment of hyperinsulinemic hypoglycaemia in adults: an update.

M V Davi, A Pia, V Guarnotta, G Pizza, A Colao, A Faggiano, NIKE Group

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of endocrinological investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Effect of sirolimus on insulin dynamics in horses.Journal of veterinary internal medicine · 2023
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Exendin-4 analogs in insulinoma theranostics.Journal of labelled compounds & radiopharmaceuticals · 2019
    Review
  15. Article
  16. Adult Nesidioblastosis in Chronic Kidney Disease.Case reports in endocrinology · 2019
    Article
  17. Review
  18. Non-surgical ablative therapies for inoperable benign insulinoma.Journal of endocrinological investigation · 2018
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

M V DaviSection of Endocrinology, Medicina Generale e Malattie Aterotrombotiche e Degenerative, Department of Medicine, University of Verona, Piazzale LA Scuro, Policlinico G.B. Rossi, 37134, Verona, Italy. mariavittoria.davi@ospedaleuniverona.it.
A PiaInternal Medicine I, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Italy.
V GuarnottaSection of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy.
G PizzaEndocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
A ColaoEndocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
A FaggianoThyroid and Parathyroid Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione G. Pascale" IRCCS, Naples, Italy.
NIKE Group
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITUniversity of Naples Federico II · ITUniversity of Verona · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTreatment of hyperinsulinemic hypoglycaemia (HH) is challenging due to the rarity of this condition and the difficulty of differential diagnosis. The aim of this article is to give an overview of the recent literature on the management of adult HH.

methodsA search for reviews, original articles, original case reports between 1995 and 2016 in PubMed using the following keywords: hyperinsulinemic hypoglycaemia, insulinoma, nesidioblastosis, gastric bypass, autoimmune hypoglycaemia, hyperinsulinism, treatment was performed.

resultsOne hundred and forty articles were selected and analysed focusing on the most recent treatments of HH.

conclusionsNew approaches to treatment of HH are available including mini-invasive surgical techniques and alternative local-regional ablative therapy for benign insulinoma and everolimus for malignant insulinoma. A correct differential diagnosis is of paramount importance to avoid unnecessary surgical operations and to implement the appropriate treatment mainly in the uncommon forms of HH, such as nesidioblastosis and autoimmune hypoglycaemia.

Indexed as

AdultHumansHyperinsulinismHypoglycemiaAutoimmune hypoglycaemiaHyperinsulinemic hypoglycaemiaInsulinomaNesidioblastosisTreatment

Identifiers

PMID27624297
OpenAlexW2520440653

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.