Evidence map›Paper›PMID 27624289›Full record

ArticleEuropean journal of immunology2016

Increased autophagy in CD4

Jorg van Loosdregt, Maura Rossetti, Roberto Spreafico, Maryam Moshref, Merissa Olmer, Gary W Williams, Pavanish Kumar, Dana Copeland, Ken Pischel, Martin Lotz and 1 more

Abstract read
In one paragraph

Article in European journal of immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 88 citations in OpenAlex.

  1. Review
  2. The significance of m6A-circFOXK2 in CD4Journal of translational autoimmunity · 2025
    Article
  3. Review
  4. Review
  5. Article
  6. Programmed Cell Death in Rheumatoid Arthritis.Journal of inflammation research · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Control of CD4Signal transduction and targeted therapy · 2023
    Article
  11. Review
  12. Article
  13. Review
  14. Autophagy pathways in autoimmune diseases.Journal of autoimmunity · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. The Role of Autophagy in the Function of CD4Frontiers in pharmacology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Jorg van LoosdregtTranslational Research Laboratory, Inflammatory and Infectious Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, USA.
Maura RossettiTranslational Research Laboratory, Inflammatory and Infectious Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, USA.
Roberto SpreaficoTranslational Research Laboratory, Inflammatory and Infectious Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, USA.
Maryam MoshrefTranslational Research Laboratory, Inflammatory and Infectious Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, USA.
Merissa OlmerDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, USA.
Gary W WilliamsDivision of Rheumatology, Scripps Clinic, San Diego, USA.
Pavanish KumarSingHealth Translational Immunology and Inflammation Centre, Duke-NUS Graduate Medical School, Singapore, Singapore.
Dana CopelandDivision of Rheumatology, Scripps Clinic, San Diego, USA.
Ken PischelDivision of Rheumatology, Scripps Clinic, San Diego, USA.
Martin LotzDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, USA.
Salvatore AlbaniTranslational Research Laboratory, Inflammatory and Infectious Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, USA.
Scripps Clinic · USSanford Burnham Prebys Medical Discovery Institute · USScripps Research Institute · USSingHealth Duke-NUS Academic Medical Centre · SGDuke-NUS Medical School · SGEureka College · US

Funding

Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Jackson · 1985 to 2026
$107.2M
TISSUE ACQUISITION, MORPHOLOGY, AND CELL CULTUREP01AG007996 · NIA · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI SAH, ROBERT L · 1989 to 2016
$26.0M
NCI NIH HHS P30 CA030199NIA NIH HHS P01 AG007996
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease hallmarked by aberrant cellular homeostasis, resulting in hyperactive CD4

Indexed as

Lymphocyte ActivationAgedAnimalsApoptosisArthritis, RheumatoidAutophagyAutophagy-Related Protein 5CD4-Positive T-LymphocytesCells, CulturedCollagen Type IIDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred DBAAtg5 protein, mouseAutophagy-Related Protein 5Collagen Type IIActivationApoptosis resistanceAutophagyRheumatoid arthritisT cells

Identifiers

PMID27624289
PMCPMC5138112
OpenAlexW2520934992

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.