SynthesisBMC psychiatry2016
Serotonin-1A receptor alterations in depression: a meta-analysis of molecular imaging studies.
Synthesis in BMC psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 5 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- A working model linking the psychopathology and pathophysiology of major depressive disorder - an umbrella review of neuroimaging studies and a conceptual framework.Molecular psychiatry · 2025Pooled it
- Cortical 5-HTMolecular psychiatry · 2025Pooled it
- EANM perspective on clinical PET and SPECT imaging in schizophrenia-spectrum disorders: a systematic review of longitudinal studies.European journal of nuclear medicine and molecular imaging · 2025Pooled it
- Neuroprotective Potency of Neolignans inFrontiers in pharmacology · 2022Pooled it
- Depression and glioblastoma, complicated concomitant diseases: a systemic review of published literature.Neurosurgical review · 2020Pooled it
- Varivax (IBRO neuroscience reports · 2026Article
- Convergent increases in serotonin 1B receptor binding following ketamine and electroconvulsive therapy: a multi-centre bayesian re-analysis of PET data.Molecular psychiatry · 2026Article
- Serotonin and working memory in mood disorder and healthy states: multi-cohort positron emission tomography study.BJPsych open · 2026Article
- Dually Acting Ligands Targeting Serotonin Receptors: Implications in CNS Disorders.Journal of medicinal chemistry · 2026Review
- The synaptic triad in depression: how stress-related pathways converge on BDNF, NMDA receptor, and MMP-9.Pharmacological reports : PR · 2026Review
- Trajectories of late-life depression: insights from molecular imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Serotonin Receptors in Areas of the Emotion Regulation Network in Human and Rat Brains-A Comparative Autoradiographic Study.The Journal of comparative neurology · 2025Article
- In vivo serotonin 1A receptor distribution in treatment-resistant depression.Translational psychiatry · 2025Article
- Dopaminergic changes in the subgenual cingulate cortex in dementia with lewy bodies associates with presence of depression.Translational psychiatry · 2025Article
- Neuro-functional correlates of personality dimensions in Parkinson's disease.Frontiers in pharmacology · 2025Article
- A computational account of joint SSRI and anti-inflammatory treatment.Frontiers in immunology · 2025Article
- Article
- The utility of PET imaging in depression.Frontiers in psychiatry · 2024Review
- PET imaging of the serotonin 1A receptor in major depressive disorder: Hierarchical multivariate analysis of [Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Dorsal raphe neurons signal integrated value during multi-attribute decision-making.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostmortem studies of people who have successfully committed suicide and people with depression have implicated the serotonin-1A (5-HT1A) receptor system in the pathophysiology of depression. Several molecular imaging studies have investigated alterations in 5-HT1A receptors in patients with depression using positron emission tomography and have reported conflicting results.
methodsWe performed a meta-analysis of studies investigating the relationship between depression and 5-HT1A binding. We conducted a comprehensive search of Medline, Embase, ScienceDirect, Scopus and Springer databases for relevant studies published between January 1999 and October 2015. The meta-analysis was conducted in accordance with the Meta-analysis of Observational Studies in Epidemiology guidelines.
resultsTen studies were included, comprising 218 patients with depression and 261 healthy controls. The results of these studies indicated a reduction in 5-HT1A receptors in mesiotemporal cortex, yielding a summary effect estimate of -0.8 (95 % CI -1.36, -0.24). Smaller reductions were reported in 5-HT1A receptor binding in the hippocampus, raphe nuclei, insular, anterior cingulate cortex and occipital cortex of people with depression. No clear effect of depression on 5-HT1A receptors was detected in the amygdala.
conclusionsReduced 5-HT1A receptor binding was associated with the pathology of depression and predicted altered serotonergic neurotransmission in various brain regions. These findings increase our understanding of the neurophysiological processes underlying depression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.