ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2016
Insulin receptor substrate-1 time-dependently regulates bone formation by controlling collagen Iα2 expression via miR-342.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Estradiol and vitamin D exert a synergistic effect on preventing osteoporosis via the miR-351-5p/IRS1 axis and mTOR/NFκB signaling pathway.Scientific reports · 2025Article
- Olanzapine affects bone formation via oralFrontiers in cellular and infection microbiology · 2025Article
- The Involvement of microRNAs in Bone Remodeling Signaling Pathways and Their Role in the Development of Osteoporosis.Biology · 2024Review
- Chitosan nanoparticles for sustained release of metformin and its derived synthetic biopolymer for bone regeneration.Frontiers in bioengineering and biotechnology · 2023Article
- Spheroid co-culture of BMSCs with osteocytes yields ring-shaped bone-like tissue that enhances alveolar bone regeneration.Scientific reports · 2022Article
- The Molten Globule State of a Globular Protein in a Cell Is More or Less Frequent Case Rather than an Exception.Molecules (Basel, Switzerland) · 2022Review
- A comprehensive analysis of the circRNA-miRNA-mRNA network in osteocyte-like cell associated with Mycobacterium leprae infection.PLoS neglected tropical diseases · 2022Article
- The oral microbiome in young women at different stages of periodontitis:Frontiers in cellular and infection microbiology · 2022Article
- Association of Sex Hormones and Fat Distribution in Men with Different Obese and Metabolic Statuses.International journal of general medicine · 2022Article
- MicroRNAs and osteocytes.Bone · 2021Review
- Exosomes Derived From M2 Macrophages Facilitate Osteogenesis and Reduce Adipogenesis of BMSCs.Frontiers in endocrinology · 2021Article
- Endoplasmic reticulum stress remodels alveolar bone formation after tooth extraction.Journal of cellular and molecular medicine · 2020Article
- Serum miR-503 is a Candidate Biomarker for Differentiating Metabolic Healthy Obesity from Metabolic Unhealthy Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- IRS-1 increases TAZ expression and promotes osteogenic differentiation in rat bone marrow mesenchymal stem cells.Biology open · 2018Article
- Methylation of Cdkn1c may be involved in the regulation of tooth development through cell cycle inhibition.Journal of molecular histology · 2018Article
- IRS-2 Partially Compensates for the Insulin Signal Defects in IRS-1Molecules and cells · 2017Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin promotes bone formation via a well-studied canonical signaling pathway. An adapter in this pathway, insulin-receptor substrate (IRS)-1, has been implicated in the diabetic osteopathy provoked by impaired insulin signaling. To further investigate IRS-1's role in the bone metabolism, we generated Irs-1-deficient Irs-1
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.