Evidence map›Paper›PMID 27623868›Full record

ReviewStem cell reviews and reports2016

Epigenetic Control of Reprogramming and Transdifferentiation by Histone Modifications.

Hua Qin, Andong Zhao, Cuiping Zhang, Xiaobing Fu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Stem cell reviews and reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
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  6. Review
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  8. High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  9. Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hua QinTianjin Medical University, Tianjin, 300070, China.
Andong ZhaoTianjin Medical University, Tianjin, 300070, China.
Cuiping ZhangKey Laboratory of Wound Repair and Regeneration of PLA, The First Hospital Affiliated to the PLA General Hospital, 51 Fu Cheng Road, Haidian District, Beijing, China.
Xiaobing FuKey Laboratory of Wound Repair and Regeneration of PLA, The First Hospital Affiliated to the PLA General Hospital, 51 Fu Cheng Road, Haidian District, Beijing, China. fuxiaobing@vip.sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Somatic cells can be reprogrammed to pluripotent stem cells or transdifferentiate to another lineage cell type. Much efforts have been made to unravel the epigenetic mechanisms underlying the cell fate conversion. Histone modifications as the major epigenetic regulator are implicated in various aspects of reprogramming and transdifferentiation. Here, we discuss the roles of histone modifications on reprogramming and transdifferentiation and hopefully provide new insights into induction and promotion of the cell fate conversion by modulating histone modifications.

Indexed as

Epigenesis, GeneticHistone CodeAnimalsCell TransdifferentiationCellular ReprogrammingHistone DeacetylasesHistone DemethylasesHumansInduced Pluripotent Stem CellsSmall Molecule LibrariesHistone DeacetylasesHistone DemethylasesSmall Molecule LibrariesCell fate conversionEpigeneticHistone modificationsiPSCsReprogrammingSomatic cellsTransdifferentiation

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.