ArticleAddiction biology2017
Essential values of cocaine and non-drug alternatives predict the choice between them.
Article in Addiction biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Effects of nonpharmacological manipulations and repeated xanomeline treatment on methamphetamine-vs-food choice in Sprague Dawley and Long Evans rats.Drug and alcohol dependence · 2026Article
- Preclinical abuse potential testing using behavioral economics and drug self-administration demand-curve analysis: A strategy to improve resolution of drug stratification for regulatory control.Pharmacological reviews · 2026Review
- Assessing behavioral reallocation after acute environmental manipulations using an asymmetric cocaine versus sucrose choice task in male and female rats.Psychopharmacology · 2026Article
- A Review of Behavioral Economic Manipulations Affecting Drug versus Nondrug Choice in Rats.Perspectives on behavior science · 2025Review
- Time to choose: impact of intertrial interval on selecting between methamphetamine and food reinforcement in male and female rats.Psychopharmacology · 2025Article
- Cocaine and heroin interact differently with nondrug reinforcers in a choice situation.Experimental and clinical psychopharmacology · 2024Article
- Intermittent-access operant alcohol self-administration promotes binge-like drinking and drinking despite negative consequences in male and female heterogeneous stock rats.Neuropharmacology · 2023Article
- Socially Integrated Polysubstance (SIP) system: An open-source solution for continuous monitoring of polysubstance fluid intake in group housed mice.Addiction neuroscience · 2023Article
- Effects of isolation housing stress and mouse strain on intravenous cocaine self-administration, sensory stimulus self-administration, and reward preference.Scientific reports · 2023Article
- Oxytocin and orexin systems bidirectionally regulate the ability of opioid cues to bias reward seeking.Translational psychiatry · 2022Article
- From concepts to treatment: a dialog between a preclinical researcher and a clinician in addiction medicine.Translational psychiatry · 2022Review
- Mile high on heroin: Lessons on the opioid epidemic from the Mile High City.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022Article
- Choosing between cocaine and sucrose under the influence: testing the effect of cocaine tolerance.Psychopharmacology · 2022Article
- Increased elasticity of sucrose demand during hyperdopaminergic states in rats.Psychopharmacology · 2022Article
- Translational opportunities in animal and human models to study alcohol use disorder.Translational psychiatry · 2021Review
- Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Demand for fentanyl becomes inelastic following extended access to fentanyl vapor self-administration.Neuropharmacology · 2021Article
- Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Non-pharmacological factors that determine drug use and addiction.Neuroscience and biobehavioral reviews · 2020Review
- The effect of economy type on heroin and saccharin essential value.Experimental and clinical psychopharmacology · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
This study investigated the relationship between reinforcer value and choice between cocaine and two non-drug alternative reinforcers in rats. The essential value (EV, a behavioral economic measure based on elasticity of demand) of intravenous cocaine and food (Experiment 1) or saccharin (Experiment 2) was determined in the first phase of each experiment. Food had higher EV than cocaine, whereas the EVs of cocaine and saccharin did not differ. In the second phase of each experiment, rats were allowed to make mutually exclusive choices between cocaine and the non-drug alternative reinforcer. The main findings were that the EV of cocaine was a positive predictor of cocaine preference and the EV of food or saccharin was a negative predictor of cocaine preference. An analysis of within-session patterns of choice behavior revealed sequential dependencies, whereby rats were more likely to choose cocaine on a particular trial after having chosen the non-drug alternative on previous trials. When the time between choices was increased, these sequential dependencies disappeared. The results of these experiments are consistent with the suggestion that addiction-like behavior involves both overvaluation of drug reinforcers and undervaluation of non-drug reinforcers.
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