ArticleJournal of biomechanics2016
The association between mechanical and biochemical/histological characteristics in diabetic and non-diabetic plantar soft tissue.
Article in Journal of biomechanics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Validation and reliability of mechanical stiffness assessment tools in multilayered polyurethane phantom models of healthy and diabetic plantar soft tissues.Scientific reports · 2025Article
- Volumetric Ultrasound of the Plantar Soft Tissue Under Bodyweight Loading.IEEE transactions on bio-medical engineering · 2025Article
- Experimental characterisation of porcine subcutaneous adipose tissue under blunt impact up to irreversible deformation.International journal of legal medicine · 2022Article
- Diabetes Status is Associated With Plantar Soft Tissue Stiffness Measured Using Ultrasound Reverberant Shear Wave Elastography Approach.Journal of diabetes science and technology · 2022Article
- The compressive, shear, biochemical, and histological characteristics of diabetic and non-diabetic plantar skin are minimally different.Journal of biomechanics · 2021Article
- Histomorphological and biochemical properties of plantar soft tissue in diabetes.Foot (Edinburgh, Scotland) · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Diabetes, and the subsequent complication of lower limb ulcers leading to potential amputation, remains an important health care problem in United States, even with declining amputation rates. It has been well documented that diabetes can alter the mechanical properties (i.e., increased stiffness) of the plantar soft tissue, although this finding is not universal. Similarly, biochemical, and histological changes have been found in the plantar soft tissue, but, as with the mechanical changes, these findings are not consistent across all studies. Our group׳s work has demonstrated that diabetes increases plantar soft tissue modulus and increases elastic septal thickness. The purpose of the current study was to explore the association between mechanical, biochemical and histological properties. Using previously collected data, a linear mixed effects regression was conducted. The correlations were weak; of the 32 that were tested, only 3 (modulus to septal thickness when location was accounted for, energy loss to total collagen, and energy loss to collagen/elastin ratio) were statistically significant, none with an R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.