ReviewArthritis research & therapy2016
Do early life factors affect the development of knee osteoarthritis in later life: a narrative review.
Review in Arthritis research & therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Pooled it
- Trial
- Long-term clinical outcomes following arthroscopic lateral retinacular release with concomitant cartilage procedures in patients with isolated patellofemoral osteoarthritis: a mean 11-year follow-up study.BMC musculoskeletal disorders · 2026Article
- Associations of health parameters at 16 years of age with structural knee MRI findings at 33 years of age in a general population-based birth cohort.Osteoarthritis and cartilage open · 2026Article
- Effect of Different Footwear on the Knee Joint: Biomechanical Analysis and Acute T2 Relaxation Time Changes After Walking in Minimalistic and Neutral Footwear.Orthopaedic journal of sports medicine · 2025Article
- The Modified Canine Groove Model of Osteoarthritis.Biomedicines · 2025Article
- Comparison of Inflammatory Biomarkers in Females with and Without Patellofemoral Pain and Associations with Patella Position, Hip and Knee Kinematics, and Pain.Biomedicines · 2025Article
- The gut microbiome and osteoarthritis.Reumatologia · 2025Review
- Article
- Associations of current and childhood socioeconomic status and health outcomes amongst patients with knee or hip osteoarthritis in a Mexico City family-practice setting.BMC musculoskeletal disorders · 2024Article
- Article
- The Magnetic Resonance Imaging Pattern of the Lesions Caused by Knee Overuse in the Pediatric Population.Medicina (Kaunas, Lithuania) · 2022Article
- Walking, running, and recreational sports for knee osteoarthritis: An overview of the evidence.European journal of rheumatology · 2022Article
- The Impact of Metabolic Syndrome on Quality of Life Among Individuals With Knee Osteoarthritis Living in Egypt.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2022Article
- Review
- Imaging and Biochemical Markers for Osteoarthritis.Diagnostics (Basel, Switzerland) · 2021Article
- Identifying Robust Risk Factors for Knee Osteoarthritis Progression: An Evolutionary Machine Learning Approach.Healthcare (Basel, Switzerland) · 2021Article
- A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Assessing Efficacy and Safety of a Novel Low-Dose Turmeric Extract Formulation in Healthy Adults with Chronic Knee Pain.Clinical pharmacology : advances and applications · 2021Article
- Osteoarthritis Progression: Mitigation and Rehabilitation Strategies.Frontiers in rehabilitation sciences · 2021Review
- Intraarticular injection of bone marrow-derived mesenchymal stem cells enhances regeneration in knee osteoarthritis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA) mainly affects older populations; however, it is possible that early life factors contribute to the development of OA in later life. The aim of this review is to describe the association between childhood or early adulthood risk factors and knee pain, structural imaging markers and development of knee OA in later life. A narrative overview of the literature synthesising the findings of literature retrieved from searches of computerised databases and manual searches was conducted. We found that only a few studies have explored the long-term effect of childhood or early adulthood risk factors on the markers of joint health that predispose people to OA or joint symptoms. High body mass index (BMI) and/or overweight status from childhood to adulthood were independently related to knee pain and OA in later life. The findings regarding the association between strenuous physical activity and knee structures in young adults are still conflicting. However, a favourable effect of moderate physical activity and fitness on knee structures is reported. Childhood physical activity and performance measures had independent beneficial effects on knee structures including knee cartilage in children and young adults. Anterior knee pain syndrome in adolescence could lead to the development of patellofemoral knee OA in the late 40s. Furthermore, weak evidence suggests that childhood malalignment, socioeconomic status and physical abuse are associated with OA in later life. The available evidence suggests that early life intervention may prevent OA in later life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.