ArticleEnvironmental health perspectives2017
Lower Placental Leptin Promoter Methylation in Association with Fine Particulate Matter Air Pollution during Pregnancy and Placental Nitrosative Stress at Birth in the ENVIRONAGE Cohort.
Article in Environmental health perspectives, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis.Environmental health perspectives · 2019Pooled it
- The Impact of Air Pollution on Our Epigenome: How Far Is the Evidence? (A Systematic Review).Current environmental health reports · 2018Pooled it
- Review
- Systemic Oxidative Stress and Antioxidant Capacity in Pregnant Women Exposed to Air Pollution: A Case-Control Study in Western Macedonia, Greece.Current issues in molecular biology · 2026Article
- Maternal PMReproductive toxicology (Elmsford, N.Y.) · 2026Article
- Prenatal air pollution exposure and placental vasculature development among participants of the UPSIDE cohort study.Environmental research · 2025Article
- Antenatal wildfire smoke exposure and preterm birth phenotypes: A retrospective cohort study.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Epigenetic reprogramming by air pollution: linking prenatal exposures to birth outcomes.Molecular and cellular biochemistry · 2025Review
- The association of prenatal ambient air pollution with placental epigenetic gestational age at birth.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Ambient Air Pollution and Congenital Heart Disease: Updated Evidence and Future Challenges.Antioxidants (Basel, Switzerland) · 2025Review
- Environmental exposures influence multigenerational epigenetic transmission.Clinical epigenetics · 2024Review
- Article
- Prenatal exposure to air pollution and BWGA Z-score: Modifying effects of placenta leukocyte telomere length and infant sex.Environmental research · 2024Article
- Association between particulate air pollution and hypertensive disorders in pregnancy: A retrospective cohort study.PLoS medicine · 2024Article
- Associations between air pollutants and acute exacerbation of drug-resistant tuberculosis: evidence from a prospective cohort study.BMC infectious diseases · 2024Article
- DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study.Clinical epigenetics · 2023Article
- The association between newborn cord blood steroids and ambient prenatal exposure to air pollution: findings from the ENVIRONAGE birth cohort.Environmental health : a global access science source · 2023Article
- Select Early-Life Environmental Exposures and DNA Methylation in the Placenta.Current environmental health reports · 2023Review
- Epigenetic mechanisms of particulate matter exposure: air pollution and hazards on human health.Frontiers in genetics · 2023Review
- Accumulation of Black Carbon Particles in Placenta, Cord Blood, and Childhood Urine in Association with the Intestinal Microbiome Diversity and Composition in Four- to Six-Year-Old Children in the ENVIREnvironmental health perspectives · 2023Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParticulate matter with a diameter ≤ 2.5 μm (PM2.5) affects human fetal development during pregnancy. Oxidative stress is a putative mechanism by which PM2.5 may exert its effects. Leptin (LEP) is an energy-regulating hormone involved in fetal growth and development.
objectivesWe investigated in placental tissue whether DNA methylation of the LEP promoter is associated with PM2.5 and whether the oxidative/nitrosative stress biomarker 3-nitrotyrosine (3-NTp) is involved.
methodsLEP DNA methylation status of 361 placentas from the ENVIRONAGE birth cohort was assessed using bisulfite-PCR-pyrosequencing. Placental 3-NTp (n = 313) was determined with an ELISA assay. Daily PM2.5 exposure levels were estimated for each mother's residence, accounting for residential mobility during pregnancy, using a spatiotemporal interpolation model.
resultsAfter adjustment for a priori chosen covariates, placental LEP methylation was 1.4% lower (95% CI: -2.7, -0.19%) in association with an interquartile range increment (7.5 μg/m3) in second-trimester PM2.5 exposure and 0.43% lower (95% CI: -0.85, -0.02%) in association with a doubling of placental 3-NTp content.
conclusionsLEP methylation status in the placenta was negatively associated with PM2.5 exposure during the second trimester, and with placental 3-NTp, a marker of oxidative/nitrosative stress. Additional research is needed to confirm our findings and to assess whether oxidative/nitrosative stress might contribute to associations between PM2.5 and placental epigenetic events. Potential consequences for health during the neonatal period and later in life warrant further exploration. Citation: Saenen ND, Vrijens K, Janssen BG, Roels HA, Neven KY, Vanden Berghe W, Gyselaers W, Vanpoucke C, Lefebvre W, De Boever P, Nawrot TS. 2017. Lower placental leptin promoter methylation in association with fine particulate matter air pollution during pregnancy and placental nitrosative stress at birth in the ENVIRONAGE cohort. Environ Health Perspect 125:262-268; http://dx.doi.org/10.1289/EHP38.
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