Evidence map›Paper›PMID 27623524›Full record

ArticleAging2016

An intestinal microRNA modulates the homeostatic adaptation to chronic oxidative stress in

Masaomi Kato, Mohammed Abul Kashem, Chao Cheng

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Maackiain Mimics Caloric Restriction throughInternational journal of molecular sciences · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. A stress-responsive miRNA regulates BMP signaling to maintain tissue homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  10. Article
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  12. Article
  13. Article
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Masaomi KatoThe Laboratory of Ageing, Centenary Institute, Camperdown, NSW 2050, Australia.
Mohammed Abul KashemThe Laboratory of Ageing, Centenary Institute, Camperdown, NSW 2050, Australia.
Chao ChengDepartment of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Lebanon, NH 03756, USA.
University of Sydney · AUDartmouth College · US

Funding

SYNERGY: The Dartmouth Center for clinical and Translational ScienceUL1TR001086 · NCATS · DARTMOUTH COLLEGE · PI GREEN, ALAN I · 2013 to 2017
$18.3M
Quantitative Biology Research InstituteP20GM103534 · NIGMS · DARTMOUTH COLLEGE · PI AMOS, CHRISTOPHER I. · 2012 to 2016
$8.6M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
SYNERGY: The Dartmouth Center for clinical and Translational ScienceKL2TR001088 · NCATS · DARTMOUTH COLLEGE · PI GREEN, ALAN I · 2013 to 2017
$3.3M
NCATS NIH HHS KL2 TR001088NCATS NIH HHS UL1 TR001086NIGMS NIH HHS P20 GM103534NIH HHS P40 OD010440
6 · The paper itself

Abstract

Adaptation to an environmental or metabolic perturbation is a feature of the evolutionary process. Recent insights into microRNA function suggest that microRNAs serve as key players in a robust adaptive response against stress in animals through their capacity to fine-tune gene expression. However, it remains largely unclear how a microRNA-modulated downstream mechanism contributes to the process of homeostatic adaptation. Here we show that loss of an intestinally expressed microRNA gene,

Indexed as

Adaptation, PhysiologicalAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCation Transport ProteinsGene Expression ProfilingHomeostasisIntestinal MucosaMicroRNAsOxidative StressSignal TransductionTranscription, GeneticUp-RegulationCaenorhabditis elegans ProteinsCation Transport ProteinsMicroRNAsadaptive responseagingC. elegansmicroRNAoxidative stress

Identifiers

PMID27623524
PMCPMC5076448
OpenAlexW2518807854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.