Evidence map›Paper›PMID 27623510›Full record

ArticleThe Journal of investigative dermatology2017

Down-Regulation of CD62L Shedding in T Cells by CD39

Karsten Mahnke, Jurgina Useliene, Sabine Ring, Paula Kage, Verena Jendrossek, Simon C Robson, Matilda Bylaite-Bucinskiene, Kerstin Steinbrink, Alexander H Enk

Abstract readComparative Study
In one paragraph

Article in The Journal of investigative dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Contact dermatitis.Nature reviews. Disease primers · 2021
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Ectonucleotidase Modulation of Lymphocyte Function in Gut and Liver.Frontiers in cell and developmental biology · 2020
    Review
  8. Review
  9. Pathomechanisms of Contact Sensitization.Current allergy and asthma reports · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Karsten MahnkeRuprecht-Karls-University Heidelberg, Department of Dermatology, Im Neuenheimer Feld 440, 69120 Heidelberg, Germany. Electronic address: karsten.mahnke@med.uni-heidelberg.de.
Jurgina UselieneRuprecht-Karls-University Heidelberg, Department of Dermatology, Im Neuenheimer Feld 440, 69120 Heidelberg, Germany; Centre of Dermatovenereology, Vilnius University Hospital Santariskiu klinikos, Vilnius, Lithuania.
Sabine RingRuprecht-Karls-University Heidelberg, Department of Dermatology, Im Neuenheimer Feld 440, 69120 Heidelberg, Germany.
Paula KageRuprecht-Karls-University Heidelberg, Department of Dermatology, Im Neuenheimer Feld 440, 69120 Heidelberg, Germany.
Verena JendrossekInstitute of Cell Biology (Cancer Research), University of Duisburg-Essen, University Hospital, Essen, Germany.
Simon C RobsonBeth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Matilda Bylaite-BucinskieneCentre of Dermatovenereology, Vilnius University Hospital Santariskiu klinikos, Vilnius, Lithuania.
Kerstin SteinbrinkDepartment of Dermatology, University Medical Center, Johannes Gutenberg-University Mainz, Mainz, Germany.
Alexander H EnkRuprecht-Karls-University Heidelberg, Department of Dermatology, Im Neuenheimer Feld 440, 69120 Heidelberg, Germany.
Heidelberg University · DEBeth Israel Deaconess Medical Center · USEssen University Hospital · DEJohannes Gutenberg University Mainz · DEVilnius University Hospital Santariskiu Klinikos · LT

Funding

XENOGRAFT TOLERANCE THROUGH MIXED CHIMERISMP01AI045897 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Megan Sykes · 2000 to 2026
$71.9M
Role of enteric glia in the death of neurons during gut inflammationR01DK103723 · NIDDK · MICHIGAN STATE UNIVERSITY · PI BRIAN D. GULBRANSEN · 2015 to 2026
$4.7M
NIAID NIH HHS P01 AI045897NIDDK NIH HHS R01 DK103723
6 · The paper itself

Abstract

Injection of regulatory T cells (Tregs) followed by sensitization with 2,4,6-trinitrochlorobenzene induced a transient increase in size and cellularity of skin-draining lymph nodes (LNs) in mice. This led us to hypothesize that Tregs may affect the trafficking of T cells from and to peripheral LNs. Two to three hours after sensitization, we found fewer CD8

Indexed as

Adenosine TriphosphateAnimalsAntigens, CDApyraseBlotting, WesternCells, CulturedDermatitis, Allergic ContactDown-RegulationEpidermal CellsEpidermisFlow CytometryImmunizationImmunologic FactorsL-SelectinLymph NodesMiceAdenosine TriphosphateAntigens, CDApyraseCD39 antigenImmunologic FactorsL-Selectin

Identifiers

PMID27623510
PMCPMC5472987
OpenAlexW2520308057

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.