Evidence map›Paper›PMID 27623240›Full record

ArticleClinical transplantation2016

The impact of bacterial colonization on graft success after total pancreatectomy with autologous islet transplantation: considerations for early definitive surgical intervention.

Joshua S Jolissaint, Linda W Langman, Claire L DeBolt, Jacob A Tatum, Allison N Martin, Andrew Y Wang, Daniel S Strand, Victor M Zaydfudim, Reid B Adams, Kenneth L Brayman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Observational
  4. Early Infectious Complications After Total Pancreatectomy with Islet Autotransplantation: a Single Center Experience.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joshua S JolissaintDepartment of Surgery, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-5595-6523
Linda W LangmanDepartment of Surgery, University of Virginia Health System, Charlottesville, VA, USA.
Claire L DeBoltDepartment of Surgery, University of Virginia Health System, Charlottesville, VA, USA.
Jacob A TatumDepartment of Surgery, University of Virginia Health System, Charlottesville, VA, USA.
Allison N MartinDepartment of Surgery, University of Virginia Health System, Charlottesville, VA, USA.
Andrew Y WangDivision of Gastroenterology and Hepatology, University of Virginia Health System, Charlottesville, VA, USA.
Daniel S StrandDivision of Gastroenterology and Hepatology, University of Virginia Health System, Charlottesville, VA, USA.
Victor M ZaydfudimDepartment of Surgery, University of Virginia Health System, Charlottesville, VA, USA.
Reid B AdamsDepartment of Surgery, University of Virginia Health System, Charlottesville, VA, USA.
Kenneth L BraymanDepartment of Surgery, University of Virginia Health System, Charlottesville, VA, USA. klb9r@virginia.edu.

Funding

Data and Statistical Coordinating Center (DSCC) for the Collaborative Islet TransUC4DK098086 · NIDDK · THE EMMES COMPANY, LLC · PI BARTON, FRANCA B · 2012 to 2012
$3.3M
NIDDK NIH HHS UC4 DK098086
6 · The paper itself

Abstract

objectiveThe purpose of this study was to determine whether bacterial contamination of islets affects graft success after total pancreatectomy with islet autotransplantation (TPIAT).

backgroundFactors associated with insulin independence after TPIAT are inconclusive. Although bacterial contamination does not preclude transplantation, the impact of bacterial contamination on graft success is unknown.

methodsPatients who received TPIAT at the University of Virginia between January 2007 and January 2016 were reviewed. Patient charts were reviewed for bacterial contamination and patients were prospectively contacted to assess rates of insulin independence.

resultsThere was no significant difference in demographic or perioperative data between patients who achieved insulin independence and those who did not. However, six of 27 patients analyzed (22.2%) grew bacterial contaminants from culture of the final islet preparations. These patients had significantly lower islet yield and C-peptide at most recent follow-up (P<.05), and none of these patients achieved insulin independence.

conclusionsIslet transplant solutions are often culture positive, likely secondary to preprocurement pancreatic manipulation and introduction of enteric flora. Although autotransplantation of culture-positive islets is safe, it is associated with higher rates of graft failure and poor islet yield. Consideration should be given to identify patients who may develop refractory chronic pancreatitis and offer early operative management to prevent bacterial colonization.

Indexed as

Islets of Langerhans TransplantationPancreatectomyAdolescentAdultDiabetes Mellitus, Type 1FemaleFollow-Up StudiesHumansInsulinIslets of LangerhansMaleMiddle AgedPancreatitis, ChronicPostoperative ComplicationsProspective StudiesRetrospective StudiesInsulinautologous islet transplantationbacteriachronic pancreatitisoutcomespancreastotal pancreatectomy with islet autotransplantationtransplantation

Identifiers

PMID27623240
PMCPMC5183974

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.