ArticleProceedings of the National Academy of Sciences of the United States of America1989
Protein evolution on rugged landscapes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed.
- Predicting the topography of fitness landscapes from the structure of genotype-phenotype maps.Genetics · 2026Article
- Interspecies interaction alters the trajectory of antibiotic resistance evolution by amplifying negative fitness epistasis.The ISME journal · 2025Article
- EvoAI enables extreme compression and reconstruction of the protein sequence space.Nature methods · 2025Article
- Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining.Nature communications · 2024Article
- EvoAI enables extreme compression and reconstruction of the protein sequence space.Research square · 2024Article
- Article
- Navigating directed evolution efficiently: optimizing selection conditions and selection output analysis.Frontiers in molecular biosciences · 2024Article
- Shifts in Mutation Bias Promote Mutators by Altering the Distribution of Fitness Effects.The American naturalist · 2023Article
- Shifts in mutation spectra enhance access to beneficial mutations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- On the incongruence of genotype-phenotype and fitness landscapes.PLoS computational biology · 2022Article
- A two-step PCR assembly for construction of gene variants across large mutational distances.Biology methods & protocols · 2021Article
- Analysis of statistical correlations between properties of adaptive walks in fitness landscapes.Royal Society open science · 2020Article
- Evolving generalists in switching rugged landscapes.PLoS computational biology · 2019Article
- Article
- Selection Limits to Adaptive Walks on Correlated Landscapes.Genetics · 2017Article
- Breaking evolutionary constraint with a tradeoff ratchet.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance.PLoS computational biology · 2015Article
- A model of substitution trajectories in sequence space and long-term protein evolution.Molecular biology and evolution · 2015Article
- Inferring fitness landscapes by regression produces biased estimates of epistasis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The changing geometry of a fitness landscape along an adaptive walk.PLoS computational biology · 2014Article
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2 authors.
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Abstract
We analyze a mathematical model of protein evolution in which the evolutionary process is viewed as hill-climbing on a random fitness landscape. In studying the structure of such landscapes, we note that a large number of local optima exist, and we calculate the time and number of mutational changes until a protein gets trapped at a local optimum. Such a hill-climbing process may underlie the evolution of antibody molecules by somatic hypermutation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.