ArticleJournal of colloid and interface science2016
Enabling Marangoni flow at air-liquid interfaces through deposition of aerosolized lipid dispersions.
Article in Journal of colloid and interface science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Complex Wave Packet Dynamics Induced by Marangoni Stresses.Industrial & engineering chemistry research · 2025Article
- Dynamics of polarization-tuned mirror symmetry breaking in a rotationally symmetric system.Nature communications · 2024Article
- Physiology and pathophysiology of human airway mucus.Physiological reviews · 2022Review
- Effect of a Surfactant Additive on Drug Transport and Distribution Uniformity After Aerosol Delivery toJournal of aerosol medicine and pulmonary drug delivery · 2022Article
- Spreading of Oil Droplets Containing Surfactants and Pesticides on Water Surface Based on the Marangoni Effect.Molecules (Basel, Switzerland) · 2021Article
- Flow regime transitions and effects on solute transport in surfactant-driven Marangoni flows.Journal of colloid and interface science · 2019Article
- Aerosolizing Lipid Dispersions Enables Antibiotic Transport Across Mimics of the Lung Airway Surface Even in the Presence of Pre-existing Lipid Monolayers.Journal of aerosol medicine and pulmonary drug delivery · 2018Article
- Surfactant-induced Marangoni transport of lipids and therapeutics within the lung.Current opinion in colloid & interface science · 2018Article
- Three-dimensional Culture of Human Airway Epithelium in Matrigel for Evaluation of Human Rhinovirus C and Bocavirus Infections.Biomedical and environmental sciences : BES · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
It has long been known that deposited drops of surfactant solution induce Marangoni flows at air-liquid interfaces. These surfactant drops create a surface tension gradient, which causes an outward flow at the fluid interface. We show that aqueous phospholipid dispersions may be used for this same purpose. In aqueous dispersions, phospholipids aggregate into vesicles that are not surface-active; therefore, drops of these dispersions do not initiate Marangoni flow. However, aerosolization of these dispersions disrupts the vesicles, allowing access to the surface-active monomers within. These lipid monomers do have the ability to induce Marangoni flow. We hypothesize that monomers released from broken vesicles adsorb on the surfaces of individual aerosol droplets and then create localized surface tension reduction upon droplet deposition. Deposition of lipid monomers via aerosolization produces surface tensions as low as 1mN/m on water. In addition, aerosolized lipid deposition also drives Marangoni flow on entangled polymer solution subphases with low initial surface tensions (∼34mN/m). The fact that aerosolization of phospholipids naturally found within pulmonary surfactant can drive Marangoni flows on low surface tension liquids suggests that aerosolized lipids may be used to promote uniform pulmonary drug delivery without the need for exogenous spreading agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.