ReviewThe American naturalist2016
Finding the Genomic Basis of Local Adaptation: Pitfalls, Practical Solutions, and Future Directions.
Review in The American naturalist, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 313 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
313 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Embracing the power of genomics to inform evolutionary significant units.The Journal of heredity · 2026Pooled it
- Two decades of resurrection studies: What have we learned about contemporary evolution of plant species?American journal of botany · 2026Pooled it
- Climate Extremes, Genomic Coverage, and Taxonomy Shape the Detection of Adaptation: A Systematic Review of GEA Studies for the Kingdom Animalia.Molecular ecology · 2026Pooled it
- Toward a Global Science of Conservation Genomics: Coldspots in Genomic Resources Highlight a Need for Equitable Collaborations and Capacity Building.Molecular ecology · 2025Pooled it
- Multi-omics integration and artificial intelligence for the conservation and utilization of local chicken genetic resources.Poultry science · 2026Review
- Integrated pangenomics and population genomics reveal climate adaptation and maladaptation in an East Asian tree.Nature communications · 2026Article
- Polygenic discrimination of leaf morphotypes in alpine Heldreichia bupleurifolia (Brassicaceae) across its natural range.Annals of botany · 2026Article
- Local Adaptation to Current but Not Future Climate in Seasonally Dry Tropical Forests: Population Genomic Evidence in a Neotropical Legume Tree.Evolutionary applications · 2026Article
- Assessing differences among elasmobranch nurseries to aid conservation based on a genomics framework.Conservation biology : the journal of the Society for Conservation Biology · 2026Article
- Putatively Adaptive and Genome-Wide Genetic Variation Often Rank Populations as Similarly Distinctive.Molecular ecology · 2026Article
- What has population genomics told us about the dynamics of selection and plant adaptation?Molecular biology and evolution · 2026Review
- A genomic perspective on adaptation to heterogeneous environments for Cycas segmentifida (Cycadaceae), an endemic cycad in southwest China.Annals of botany · 2026Article
- Population genomic assessment of Dudleya brevifolia for in situ conservation management.Annals of botany · 2026Article
- Parallel adaptation to geothermally-warmed habitats due to common structural variation and functional developmental pathways.Nature communications · 2026Article
- Adaptation across an extreme elevational gradient in Andean leaf-eared mice, the world's highest-dwelling mammal.Science (New York, N.Y.) · 2026Article
- Using herbarium collections to study genetic responses to global change.The New phytologist · 2026Review
- Outpaced by Drought: Weak Local Adaptation and Limited Potential for Drought Adaptation in a Deciduous Conifer.Evolutionary applications · 2026Article
- Morphological, anatomical, and spatial adaptation of Calotropis procera populations across climatic and geographic gradients in Iran.BMC plant biology · 2026Article
- Genomic Insights into Genetic Diversity of Coilia nasus Across Wild Ecotypes and Farmed Populations in China.Marine biotechnology (New York, N.Y.) · 2026Article
- Multiple modes of selection underlie repeated and human-mediated adaptation in a formerly migratory fish.Molecular biology and evolution · 2026Article
253 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Uncovering the genetic and evolutionary basis of local adaptation is a major focus of evolutionary biology. The recent development of cost-effective methods for obtaining high-quality genome-scale data makes it possible to identify some of the loci responsible for adaptive differences among populations. Two basic approaches for identifying putatively locally adaptive loci have been developed and are broadly used: one that identifies loci with unusually high genetic differentiation among populations (differentiation outlier methods) and one that searches for correlations between local population allele frequencies and local environments (genetic-environment association methods). Here, we review the promises and challenges of these genome scan methods, including correcting for the confounding influence of a species' demographic history, biases caused by missing aspects of the genome, matching scales of environmental data with population structure, and other statistical considerations. In each case, we make suggestions for best practices for maximizing the accuracy and efficiency of genome scans to detect the underlying genetic basis of local adaptation. With attention to their current limitations, genome scan methods can be an important tool in finding the genetic basis of adaptive evolutionary change.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.