Evidence map›Paper›PMID 27622773›Full record

ArticleJournal of the American Chemical Society2016

Evolutionary Gain of Alanine Mischarging to Noncognate tRNAs with a G4:U69 Base Pair.

Litao Sun, Ana Cristina Gomes, Weiwei He, Huihao Zhou, Xiaoyun Wang, David W Pan, Paul Schimmel, Tao Pan, Xiang-Lei Yang

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Perseverance of protein homeostasis despite mistranslation of glycine codons with alanine.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Article
  12. Review
  13. CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  14. Article
  15. Article
  16. Information theory unveils the evolution of tRNA identity elements in the three domains of life.Theory in biosciences = Theorie in den Biowissenschaften · 2020
    Article
  17. Review
  18. A Synthetic Reporter for Probing Mistranslation in Living Cells.Frontiers in bioengineering and biotechnology · 2020
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Litao SunDepartment of Cell and Molecular Biology, The Scripps Research Institute , La Jolla, California 92037, United States.
Ana Cristina GomesDepartment of Biochemistry and Molecular Biology, University of Chicago , Chicago, Illinois 60637, United States.
Weiwei HeDepartment of Chemical Physiology, The Scripps Research Institute , La Jolla, California 92037, United States.
Huihao ZhouDepartment of Cell and Molecular Biology, The Scripps Research Institute , La Jolla, California 92037, United States.
Xiaoyun WangDepartment of Biochemistry and Molecular Biology, University of Chicago , Chicago, Illinois 60637, United States.
David W PanDepartment of Biochemistry and Molecular Biology, University of Chicago , Chicago, Illinois 60637, United States.
Paul SchimmelDepartment of Cell and Molecular Biology, The Scripps Research Institute , La Jolla, California 92037, United States.
Tao PanDepartment of Biochemistry and Molecular Biology, University of Chicago , Chicago, Illinois 60637, United States.
Xiang-Lei YangDepartment of Cell and Molecular Biology, The Scripps Research Institute , La Jolla, California 92037, United States.

Funding

Mis-translation as a new mechanism of stress response in biologyDP1GM105386 · NIGMS · UNIVERSITY OF CHICAGO · PI PAN, TAO · 2012 to 2015
$3.1M
Elucidating pathological mechanism of DI-CMTCR01NS085092 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI YANG, XIANG-LEI · 2013 to 2017
$2.2M
NIGMS NIH HHS DP1 GM105386NINDS NIH HHS R01 NS085092
6 · The paper itself

Abstract

Fidelity of translation, which is predominately dictated by the accuracy of aminoacyl-tRNA synthetases in pairing amino acids with correct tRNAs, is of central importance in biology. Yet, deliberate modifications of translational fidelity can be beneficial. Here we found human and not E. coli AlaRS has an intrinsic capacity for mispairing alanine onto nonalanyl-tRNAs including tRNA

Indexed as

AlanineEvolution, MolecularAmino Acyl-tRNA SynthetasesBase PairingCrystallography, X-RayEscherichia coliRNA, TransferAlanineAmino Acyl-tRNA SynthetasesRNA, Transfer

Identifiers

PMID27622773
PMCPMC5356932

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.