Evidence map›Paper›PMID 27622677›Full record

ArticleBrain, behavior, and immunity2017

Behavioral impact of maternal allergic-asthma in two genetically distinct mouse strains.

Jared J Schwartzer, Milo Careaga, Morgan A Coburn, Destanie R Rose, Heather K Hughes, Paul Ashwood

Abstract read
In one paragraph

Article in Brain, behavior, and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Strain-Dependent Protective Innate Immunity AgainstJournal of fungi (Basel, Switzerland) · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Preclinical models of maternal asthma and progeny outcomes: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Immune Dysregulation in Autism Spectrum Disorder: What Do We Know about It?International journal of molecular sciences · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jared J SchwartzerProgram in Neuroscience and Behavior, Department of Psychology and Education, Mount Holyoke College, 50 College Street, South Hadley, MA 01075, United States. Electronic address: jjschwar@mtholyoke.edu.
Milo CareagaThe M.I.N.D. Institute, University of California, Davis, 2825 50th Street, Sacramento, CA 95817, United States; Department of Medical Microbiology and Immunology, University of California, Davis, One Shields Avenue, Davis, CA 95616, United States.
Morgan A CoburnProgram in Neuroscience and Behavior, Department of Psychology and Education, Mount Holyoke College, 50 College Street, South Hadley, MA 01075, United States.
Destanie R RoseThe M.I.N.D. Institute, University of California, Davis, 2825 50th Street, Sacramento, CA 95817, United States; Department of Medical Microbiology and Immunology, University of California, Davis, One Shields Avenue, Davis, CA 95616, United States.
Heather K HughesThe M.I.N.D. Institute, University of California, Davis, 2825 50th Street, Sacramento, CA 95817, United States; Department of Medical Microbiology and Immunology, University of California, Davis, One Shields Avenue, Davis, CA 95616, United States.
Paul AshwoodThe M.I.N.D. Institute, University of California, Davis, 2825 50th Street, Sacramento, CA 95817, United States; Department of Medical Microbiology and Immunology, University of California, Davis, One Shields Avenue, Davis, CA 95616, United States. Electronic address: pashwood@ucdavis.edu.
University of California, Davis · USMount Holyoke College · US

Funding

UC Davis Biology ProgramR25GM056765 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI GOMES, ALDRIN V. · 1998 to 2019
$9.7M
Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ABBEDUTO, LEONARD J. · 2013 to 2019
$8.5M
Interdisciplinary Training for Autism Researchers(RMI)T32MH073124 · NIMH · UNIVERSITY OF CALIFORNIA DAVIS · PI Stephen Charles Noctor, Christine Wu Nordahl · 2004 to 2026
$6.8M
Mouse model of maternal allergic asthma and offspring autism-like behavioral deficitsR15HD082638 · NICHD · MOUNT HOLYOKE COLLEGE · PI SCHWARTZER, JARED · 2015 to 2015
$433k
The effects of environmental air pollutants on maternal allergic asthma and its neurobiological consequencesR21ES025560 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ASHWOOD, PAUL · 2017 to 2018
$432k
Maternal asthma and brain developmentR21MH116383 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ASHWOOD, PAUL · 2018 to 2019
$432k
NICHD NIH HHS R15 HD082638NICHD NIH HHS U54 HD079125NIEHS NIH HHS R21 ES025560NIGMS NIH HHS R25 GM056765NIMH NIH HHS T32 MH073124
6 · The paper itself

Abstract

Recent population-based studies of expecting mothers identified a unique profile of immune markers that are associated with an increased risk of having a child diagnosed with autism spectrum disorder (ASD). This immune profile, including increased levels of maternal and placental interleukin (IL)-4 and IL-5, is consistent with an immune response found in an allergic-asthma phenotype. Allergies and asthma reflect an imbalance in immune responses including polarization towards T-helper type 2 (T

Indexed as

AnimalsAsthmaAutism Spectrum DisorderBehavior, AnimalCytokinesDisease Models, AnimalFemaleGene-Environment InteractionMaleMaternal ExposureMiceMice, Inbred C57BLOvalbuminPregnancyPrenatal Exposure Delayed EffectsTh2 CellsCytokinesOvalbuminAllergiesAnimal modelASDAsthmaAutismMaternal immune activationTranslational

Identifiers

PMID27622677
PMCPMC5346064
OpenAlexW2519114521

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.