ArticleBrain, behavior, and immunity2017
Chronic stress is associated with reduced circulating hematopoietic progenitor cell number: A maternal caregiving model.
Article in Brain, behavior, and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Caregiving and Hypertension in Younger Black Women: The Jackson Heart Study.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Factors Predicting Poor Mental and Physical Health in Parents of Children with Autism Spectrum Disorder: Results from 2016 to 2019 National Survey of Children's Health.Journal of autism and developmental disorders · 2024Article
- Development and evaluation of a family-child reading picture book on reducing autism spectrum disorder caregivers' psychological stress: a mixed method study.Frontiers in psychiatry · 2024Article
- Article
- Perceived stress in Chinese patients with coronary heart disease: a cross-sectional study.BMJ open · 2022Article
- An ignored minority status: Consequences for sexual minorities living in a biased society.Social and personality psychology compass · 2021Article
- Associations between increased circulating endothelial progenitor cell levels and anxiety/depressive severity, cognitive deficit and function disability among patients with major depressive disorder.Scientific reports · 2021Article
- Adversity in early life and pregnancy are immunologically distinct from total life adversity: macrophage-associated phenotypes in women exposed to interpersonal violence.Translational psychiatry · 2021Article
- Early life adversity, pubertal timing, and epigenetic age acceleration in adulthood.Developmental psychobiology · 2021Article
- Minimally-invasive methods for examining biological changes in response to chronic stress: A scoping review.International journal of nursing studies · 2020Article
- Stress resilience: Narrative identity may buffer the longitudinal effects of chronic caregiving stress on mental health and telomere shortening.Brain, behavior, and immunity · 2019Article
- Maternal caregivers have confluence of altered cortisol, high reward-driven eating, and worse metabolic health.PloS one · 2019Article
- Chronic Stress and Impulsive Risk-Taking Predict Increases in Visceral Fat over 18 Months.Obesity (Silver Spring, Md.) · 2018Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundChronic psychological stress is a risk factor for cardiovascular disease and mortality. Circulating hematopoietic progenitor cells (CPCs) maintain vascular homeostasis, correlate with preclinical atherosclerosis, and prospectively predict cardiovascular events. We hypothesize that (1) chronic caregiving stress is related to reduced CPC number, and (2) this may be explained in part by negative interactions within the family.
methodsWe investigated levels of stress and CPCs in 68 healthy mothers - 31 of these had children with an autism spectrum disorder (M-ASD) and 37 had neurotypical children (M-NT). Participants provided fasting blood samples, and CD45
resultsM-ASD exhibited lower CPCs than M-NT (Cohen's d=0.83; p⩽0.01), controlling for age, BMI, and physical activity. Across the whole sample, positive interactions were related to higher CPCs, and negative interactions to lower CPCs (allp's<0.05). The adverse effects of group on CPCs were significantly mediated through negative interactions with the child (indirect β=-0.24, p⩽0.01). In the full model, greater age (β=-0.19, p=0.04), BMI (β=-0.18, p=0.04), and negative interactions with the child (β=-0.33, p<0.01) were independently associated with lower CPCs. M-ASD had a less healthy lipid profile (total cholesterol/HDL), which in turn, was associated with lower CPCs.
conclusionsChronic stress adversely impacts CPC number, an early-stage biomarker that predicts subclinical atherosclerosis and future CVD events, independent of traditional cardiovascular risk factors and inflammatory factors. Among maternal caregivers, child-related interpersonal stress appears to be a key psychological predictor of stress-related CVD risk.
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