ArticleHuman brain mapping2017
Diffusion tensor imaging of white matter and correlates to eye movement control and psychometric testing in children with prenatal alcohol exposure.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- White matter microstructure in fetal alcohol spectrum disorders: A systematic review of diffusion tensor imaging studies.Human brain mapping · 2019Pooled it
- Prenatal exposure to alcohol and its impact on reward processing and substance use in adulthood.Translational psychiatry · 2024Article
- Subcortical volume in middle-aged adults with fetal alcohol spectrum disorders.Brain communications · 2024Article
- Disrupted dynamic functional network connectivity in fetal alcohol spectrum disorders.Alcohol, clinical & experimental research · 2023Article
- Capacitive Eye Tracker Made of Fractured Carbon Nanotube-Paper Composites for Wearable Applications.Sensors and actuators. A, Physical · 2022Article
- Trajectories of brain white matter development in young children with prenatal alcohol exposure.Human brain mapping · 2022Article
- Prenatal depression exposure alters white matter integrity and neurodevelopment in early childhood.Brain imaging and behavior · 2022Article
- Central white matter integrity alterations in 2-3-year-old children following prenatal alcohol exposure.Drug and alcohol dependence · 2021Article
- Article
- Functional connectivity of the attention networks is altered and relates to neuropsychological outcomes in children with prenatal alcohol exposure.Developmental cognitive neuroscience · 2021Article
- In utero MRI identifies consequences of early-gestation alcohol drinking on fetal brain development in rhesus macaques.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The brain's functional connectome in young children with prenatal alcohol exposure.NeuroImage. Clinical · 2019Article
- Effects of ethanol and varenicline on female Sprague-Dawley rats in a third trimester model of fetal alcohol syndrome.Alcohol (Fayetteville, N.Y.) · 2018Article
- Sensorimotor network alterations in children and youth with prenatal alcohol exposure.Human brain mapping · 2018Article
- Hypersynchrony in MEG spectral amplitude in prospectively-identified 6-month-old infants prenatally exposed to alcohol.NeuroImage. Clinical · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal alcohol exposure (PAE) can cause central nervous system dysfunction and widespread structural anomalies as detected by magnetic resonance imaging (MRI). This study focused on diffusion tensor imaging (DTI) of white matter in a large sample of PAE participants that allowed us to examine correlations with behavioral outcomes. Participants were confirmed PAE (n = 69, mean age = 12.5 ± 3.2 years) or typically developing control children (n = 67, mean age = 12.1 ± 3.2 years) who underwent brain MRI, eye movement tasks, and psychometric tests. A semi-automated tractography method extracted fractional anisotropy (FA) and mean diffusivity (MD) values from 15 white matter tracts. The PAE group displayed decreased FA compared with controls in multiple tracts including 3 corpus callosum regions, right corticospinal tract, and 3 left hemisphere tracts connecting to the frontal lobe (cingulum, uncinate fasciculus, and superior longitudinal fasciculus). Significant group by sex interactions were found for the genu, left superior longitudinal fasciculus, and the left uncinate, with females in the PAE group exhibiting lower FA compared with control females. Correlations were found between DTI and eye movement measures in the control group, but these same relationships were absent in the PAE group. In contrast, no correlations were found between DTI and any of the psychometric tests used in this study. These findings support the hypothesis that measures of eye movement control may be valuable functional biomarkers of the brain injury induced by PAE as these tasks reveal group differences that appear to be linked to deficits in white matter integrity in the brain. Hum Brain Mapp 38:444-456, 2017. © 2016 Wiley Periodicals, Inc.
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