Evidence map›Paper›PMID 27622551›Full record

ArticlePloS one2016

Pilot Assessment of Brain Metabolism in Perinatally HIV-Infected Youths Using Accelerated 5D Echo Planar J-Resolved Spectroscopic Imaging.

Zohaib Iqbal, Neil E Wilson, Margaret A Keller, David E Michalik, Joseph A Church, Karin Nielsen-Saines, Jaime Deville, Raissa Souza, Mary-Lynn Brecht, M Albert Thomas

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In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zohaib IqbalDepartment of Radiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States of America.
Neil E WilsonDepartment of Radiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States of America.
Margaret A KellerLos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, CA, 90502, United States of America.
David E MichalikDepartment of Pediatrics, Miller Children's Hospital at Long Beach, Long Beach, CA, 90806, United States of America.
Joseph A ChurchDepartment of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, 90027, United States of America.
Karin Nielsen-SainesDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States of America.
Jaime DevilleDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States of America.
Raissa SouzaDepartment of Radiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States of America.
Mary-Lynn BrechtDepartment of Behavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States of America.
M Albert ThomasDepartment of Radiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, United States of America.

Funding

Compressed Sensing 5D Spectroscopic Imaging of Perinatally HIV-Infected YouthR21NS080649 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMAS, MICHAEL ALBERT · 2012 to 2013
$391k
NINDS NIH HHS R21 NS080649
6 · The paper itself

Abstract

purposeTo measure cerebral metabolite levels in perinatally HIV-infected youths and healthy controls using the accelerated five dimensional (5D) echo planar J-resolved spectroscopic imaging (EP-JRESI) sequence, which is capable of obtaining two dimensional (2D) J-resolved spectra from three spatial dimensions (3D). MATERIALS AND

methodsAfter acquisition and reconstruction of the 5D EP-JRESI data, T1-weighted MRIs were used to classify brain regions of interest for HIV patients and healthy controls: right frontal white (FW), medial frontal gray (FG), right basal ganglia (BG), right occipital white (OW), and medial occipital gray (OG). From these locations, respective J-resolved and TE-averaged spectra were extracted and fit using two different quantitation methods. The J-resolved spectra were fit using prior knowledge fitting (ProFit) while the TE-averaged spectra were fit using the advanced method for accurate robust and efficient spectral fitting (AMARES).

resultsQuantitation of the 5D EP-JRESI data using the ProFit algorithm yielded significant metabolic differences in two spatial locations of the perinatally HIV-infected youths compared to controls: elevated NAA/(Cr+Ch) in the FW and elevated Asp/(Cr+Ch) in the BG. Using the TE-averaged data quantified by AMARES, an increase of Glu/(Cr+Ch) was shown in the FW region. A strong negative correlation (r < -0.6) was shown between tCh/(Cr+Ch) quantified using ProFit in the FW and CD4 counts. Also, strong positive correlations (r > 0.6) were shown between Asp/(Cr+Ch) and CD4 counts in the FG and BG.

conclusionThe complimentary results using ProFit fitting of J-resolved spectra and AMARES fitting of TE-averaged spectra, which are a subset of the 5D EP-JRESI acquisition, demonstrate an abnormal energy metabolism in the brains of perinatally HIV-infected youths. This may be a result of the HIV pathology and long-term combinational anti-retroviral therapy (cART). Further studies of larger perinatally HIV-infected cohorts are necessary to confirm these findings.

Indexed as

AdolescentAIDS Dementia ComplexAlgorithmsAnti-HIV AgentsAspartic AcidBrainCase-Control StudiesCholineCreatineEcho-Planar ImagingEnergy MetabolismFemaleFunctional NeuroimagingGlutamic AcidHIV InfectionsHumansAnti-HIV AgentsAspartic AcidCholineCreatineGlutamic AcidN-acetylaspartate

Identifiers

PMID27622551
PMCPMC5021365

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.