ArticlePloS one2016
Time-Course of Changes in Choroidal Thickness after Complete Mydriasis Induced by Compound Tropicamide in Children.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Repeatability, reproducibility, and agreement for three optical coherence tomography instruments.BMC ophthalmology · 2025Article
- Superior visual quality outcomes with compound tropicamide eye drops in treating juvenile pseudomyopia.American journal of translational research · 2025Article
- Effect of mydriasis on macular and peripapillary metrics in swept-source optical coherence tomography angiography.Frontiers in endocrinology · 2024Article
- Choroidal Thickness in Indigenous Australian Children.Translational vision science & technology · 2020Article
- Adverse Cardiovascular Effects of Phenylephrine Eye Drops Combined With Intravenous Atropine.Frontiers in pharmacology · 2020Article
- Retinal Artery Contraction After Phenylephrine as a Cardiovascular Risk Biomarker.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
- Peripapillary and macular choroidal thickness before and after phenylephrine instillation.Eye (London, England) · 2019Article
- The effect of topical administration of cyclopentolate on ocular biometry: An analysis for mouse and human models.Scientific reports · 2017Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to investigate the time-course of changes in choroidal thickness (ChT) following complete mydriasis induced by compound tropicamide.
methodsChT was measured by OCT with the enhanced-depth imaging technique (Spectralis HRA+OCT, Heidelberg Engineering, Germany) at nine locations of the fundus: subfoveal ChT (SFChT) and ChT at 1 mm and 3 mm from the fovea in four quadrants. Mydriasis was induced with compound tropicamide (0.5% tropicamide plus 0.5% phenylephrine hydrochloride, three doses at 5-minute intervals). Measurements were conducted prior to the instillation and at 0, 30, and 60 min following complete mydriasis. Results at different time-points were compared using repeated-measures ANOVA to investigate the time-course of the changes.
resultsThirty-nine subjects (mean age 11.9±2 years; 16 males and 23 females) were enrolled in the study. Compound tropicamide resulted in a statistically significant decrease in SFChT at 0, 30, and 60 min after complete mydriasis, as compared to baseline (-5±4 μm, -12±4 μm, and -13±4 μm, respectively; all P<0.0001). No significant changes were detected in the parafoveal choroid except at 1 mm temporal (T1mm) and nasal (N1mm) to the fovea at 30 and 60 min (T1mm: -6±4 μm and -7±5 μm at 30 and 60 min; N1mm: -6±4 μm and -7±5 μm at 30 and 60 min, respectively; all P<0.0001). Repeated-measures ANOVA showed a significant interaction between the time after complete mydriasis and the effect of the mydriasis agent.
conclusionsComplete mydriasis induced by compound tropicamide led to choroidal thinning, and the magnitude varied over time.
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