Evidence map›Paper›PMID 27622466›Full record

ArticleScientific reports2016

From Biological Cilia to Artificial Flow Sensors: Biomimetic Soft Polymer Nanosensors with High Sensing Performance.

Mohsen Asadnia, Ajay Giri Prakash Kottapalli, K Domenica Karavitaki, Majid Ebrahimi Warkiani, Jianmin Miao, David P Corey, Michael Triantafyllou

Abstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Review
  2. Hydrogel-based neural engineering for skin wound healing.Frontiers in cell and developmental biology · 2026
    Review
  3. Nature-Inspired Innovation in Electrical Engineering Technologies and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Actuation-enhanced multifunctional sensing and information recognition by magnetic artificial cilia arrays.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. A nanonewton-scale biomimetic mechanosensor.Microsystems & nanoengineering · 2023
    Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohsen AsadniaSchool of Mechanical &Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798 Singapore.
Ajay Giri Prakash KottapalliCenter for Environmental Sensing and Modeling (CENSAM) IRG Singapore-MIT Alliance for Research and Technology (SMART) Centre, 3 Science Drive 2, 117543 Singapore.
K Domenica KaravitakiHoward Hughes Medical Institute and Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Majid Ebrahimi WarkianiSchool of Mechanical and Manufacturing Engineering, Australian Centre for NanoMedicine, University of New South Wales, Sydney, New South Wales 2052, Australia.
Jianmin MiaoSchool of Mechanical &Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798 Singapore.
David P CoreyHoward Hughes Medical Institute and Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Michael TriantafyllouCenter for Environmental Sensing and Modeling (CENSAM) IRG Singapore-MIT Alliance for Research and Technology (SMART) Centre, 3 Science Drive 2, 117543 Singapore.

Funding

MOLECULAR MECHANISMS OF AUDITORY TRANSDUCTIONR01DC000304 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI DAVID P COREY, Marcos Sotomayor · 1989 to 2026
$9.3M
NIDCD NIH HHS R01 DC000304
6 · The paper itself

Abstract

We report the development of a new class of miniature all-polymer flow sensors that closely mimic the intricate morphology of the mechanosensory ciliary bundles in biological hair cells. An artificial ciliary bundle is achieved by fabricating bundled polydimethylsiloxane (PDMS) micro-pillars with graded heights and electrospinning polyvinylidenefluoride (PVDF) piezoelectric nanofiber tip links. The piezoelectric nature of a single nanofiber tip link is confirmed by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). Rheology and nanoindentation experiments are used to ensure that the viscous properties of the hyaluronic acid (HA)-based hydrogel are close to the biological cupula. A dome-shaped HA hydrogel cupula that encapsulates the artificial hair cell bundle is formed through precision drop-casting and swelling processes. Fluid drag force actuates the hydrogel cupula and deflects the micro-pillar bundle, stretching the nanofibers and generating electric charges. Functioning with principles analogous to the hair bundles, the sensors achieve a sensitivity and threshold detection limit of 300 mV/(m/s) and 8 μm/s, respectively. These self-powered, sensitive, flexible, biocompatibale and miniaturized sensors can find extensive applications in navigation and maneuvering of underwater robots, artificial hearing systems, biomedical and microfluidic devices.

Indexed as

AnimalsBiocompatible MaterialsBiomimetic MaterialsBiosensing TechniquesCiliaDimethylpolysiloxanesEquipment DesignFluorocarbon PolymersHair Cells, AuditoryHydrogelsMechanical PhenomenaMechanotransduction, CellularMicro-Electrical-Mechanical SystemsNanofibersNanotechnologyPolyvinylsBiocompatible MaterialsDimethylpolysiloxanesFluorocarbon PolymersHydrogelspolyvinylidene fluoridePolyvinyls

Identifiers

PMID27622466
PMCPMC5020657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.