Evidence map›Paper›PMID 27622243›Full record

ArticleCellular and molecular life sciences : CMLS2017

Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair.

Farima Zahedi, Maliheh Nazari-Jahantigh, Zhe Zhou, Pallavi Subramanian, Yuanyuan Wei, Jochen Grommes, Stefan Offermanns, Sabine Steffens, Christian Weber, Andreas Schober

Open access · greenAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  8. MicroRNAs in Genetic Etiology of Human Diseases.Methods in molecular biology (Clifton, N.J.) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Farima ZahediInstitute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, 80336, Munich, Germany.
Maliheh Nazari-JahantighInstitute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, 80336, Munich, Germany.
Zhe ZhouInstitute for Molecular Cardiovascular Research, RWTH Aachen University, 52074, Aachen, Germany.
Pallavi SubramanianInstitute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, 80336, Munich, Germany.
Yuanyuan WeiInstitute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, 80336, Munich, Germany.
Jochen GrommesEuropean Vascular Center Aachen-Maastricht, Medical University Maastricht, 6229 HX, Maastricht, The Netherlands.
Stefan OffermannsMax Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany.
Sabine SteffensInstitute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, 80336, Munich, Germany.
Christian WeberInstitute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, 80336, Munich, Germany.
Andreas SchoberInstitute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, 80336, Munich, Germany. aschober@med.lmu.de.ORCID 0000-0001-7798-136X
German Centre for Cardiovascular Research · DEBGI Group (China) · CNLudwig-Maximilians-Universität München · DEMaastricht University · NLMax Planck Institute for Heart and Lung Research · DEUniversity Hospital Carl Gustav Carus · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) coordinate vascular repair by regulating injury-induced gene expression in vascular smooth muscle cells (SMCs) and promote the transition of SMCs from a contractile to a proliferating phenotype. However, the effect of miRNA expression in SMCs on neointima formation is unclear. Therefore, we studied the role of miRNA biogenesis by Dicer in SMCs in vascular repair. Following wire-induced injury to carotid arteries of Apolipoprotein E knockout (Apoe

Indexed as

Gene Regulatory NetworksAnimalsArteriesCell ProliferationFemaleGene DeletionGene Expression ProfilingGene Expression RegulationHEK293 CellsHumansMaleMiceMicroRNAsMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaMicroRNAsRho Guanine Nucleotide Exchange FactorsRibonuclease IIIRNA, MessengerARHGEF26Cell proliferationDicerMicroRNASmooth muscle cells

Identifiers

PMID27622243
PMCPMC11107738
OpenAlexW2518721769

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.