Evidence map›Paper›PMID 27622146›Full record

ArticleWorld journal of orthopedics2016

Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection.

Jessica Amber Jennings, Karen E Beenken, Robert A Skinner, Daniel G Meeker, Mark S Smeltzer, Warren O Haggard, Karen S Troxel

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of orthopedics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  8. Innovations in osteomyelitis research: A review of animal models.Animal models and experimental medicine · 2021
    Review
  9. Review
  10. Therapeutics and delivery vehicles for local treatment of osteomyelitis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
    Review
  11. Review
  12. Review
  13. Article
  14. CORR InsightsClinical orthopaedics and related research · 2017
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jessica Amber JenningsJessica Amber Jennings, Warren O Haggard, Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, United States.
Karen E BeenkenJessica Amber Jennings, Warren O Haggard, Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, United States.
Robert A SkinnerJessica Amber Jennings, Warren O Haggard, Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, United States.
Daniel G MeekerJessica Amber Jennings, Warren O Haggard, Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, United States.
Mark S SmeltzerJessica Amber Jennings, Warren O Haggard, Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, United States.
Warren O HaggardJessica Amber Jennings, Warren O Haggard, Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, United States.
Karen S TroxelJessica Amber Jennings, Warren O Haggard, Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, United States.
Creative Research Enterprises (United States) · USUniversity of Memphis · USZimmer Biomet (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo test antibiotic-loaded coating for efficacy in reducing bacterial biofilm and development of osteomyelitis in an orthopaedic model of implant infection.

methodsPhosphatidylcholine coatings loaded with 25% vancomycin were applied to washed and sterilized titanium wires 20 mm in length. A 10 mm segment was removed from rabbit radius (total = 9; 5 coated, 4 uncoated), and the segment was injected with 1 × 10(6) colony forming units (CFUs) of Staphylococcus aureus (UAMS-1 strain). Titanium wires were inserted through the intramedullary canal of the removed segment and into the proximal radial segment and the segment was placed back into the defect. After 7 d, limbs were removed, X-rayed, swabbed for tissue contamination. Wires were removed and processed to determine attached CFUs. Tissue was swabbed and streaked on agar plates to determine bacteriological score.

resultsAntibiotic-loaded coatings resulted in significantly reduced biofilm formation (4.7 fold reduction in CFUs; P < 0.001) on titanium wires and reduced bacteriological score in surrounding tissue (4.0 ± 0 for uncoated, 1.25 ± 0.5 for coated; P = 0.01). Swelling and pus formation was evident in uncoated controls at the 7 d time point both visually and radiographically, but not in antibiotic-loaded coatings.

conclusionActive antibiotic was released from coated implants and significantly reduced signs of osteomyelitic symptoms. Implant coatings were well tolerated in bone. Further studies with additional control groups and longer time periods are warranted. Antibiotic-loaded phosphatidylcholine coatings applied at the point of care could prevent implant-associated infection in orthopaedic defects.

Indexed as

AntibioticBiofilmDrug delivery coatingImplantOrthopaedic infection

Identifiers

PMID27622146
PMCPMC4990767
OpenAlexW2529403635

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.