ArticleNeuroImage. Clinical2016
Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET.
Article in NeuroImage. Clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- The historical progression of positron emission tomography research in neuroendocrinology.Frontiers in neuroendocrinology · 2023Pooled it
- An Evaluation Study of PET Image Quality Factors in Brain Tumor Diagnosis.Tomography (Ann Arbor, Mich.) · 2026Article
- Increased Resting-State Functional Connectivity in Patients With Autoimmune Addison Disease.The Journal of clinical endocrinology and metabolism · 2024Article
- Dexamethasone suppression forCancer imaging : the official publication of the International Cancer Imaging Society · 2023Article
- Correction of Hypercortisolemia with an Improved Cognitive Function and Muscle Mass after Transsphenoidal Surgery in an Older Patient with Cushing's Disease.Internal medicine (Tokyo, Japan) · 2022Article
- A novel rabbit fixator made of a thermoplastic mask for awake imaging experiments.Scientific reports · 2021Article
- Dynamic changes of views on the brain changes of Cushing's syndrome using different computer-assisted tool.Reviews in endocrine & metabolic disorders · 2020Review
- Reversibility of cerebral blood flow in patients with Cushing's disease after surgery treatment.Metabolism: clinical and experimental · 2020Article
- Improvement in cognitive impairment following the successful treatment of endogenous Cushing's syndrome-a case report and literature review.BMC endocrine disorders · 2019Review
- Voxel-based comparison of brain glucose metabolism between patients with Cushing's disease and healthy subjects.NeuroImage. Clinical · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic exposure to elevated levels of glucocorticoids can exert a neurotoxic effect in patients, possibly manifesting as molecular imaging alterations in patients. The aim of this study was to investigate the potential association between brain metabolism and elevated hormone level using (18)F-fluorodeoxyglucose positron emission tomography. We retrospectively enrolled 92 consecutive patients with confirmed diagnosis of Cushing's disease. A voxel-based analysis was performed to investigate the association between cerebral (18)F-fluorodeoxyglucose uptake and serum cortisol level. Relatively impaired metabolism of specific brain regions correlated with serum cortisol level was found. Specifically, notable correlations were found in the hippocampus, amygdala, and cerebellum, regions considered to be involved in the regulation and central action of glucocorticoids. Moreover, some hormone-associated regions were found in the frontal and occipital cortex, possibly mediating the cognitive changes seen in Cushing's disease. Our findings link patterns of perturbed brain metabolism relates to individual hormone level, thus presenting a substrate for cognitive disturbances seen in Cushing's disease patients, as well as in other conditions with abnormal cortisol levels.
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