ArticleNeuroImage. Clinical2016
Reduced load-dependent default mode network deactivation across executive tasks in schizophrenia spectrum disorders.
Article in NeuroImage. Clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Shared and distinct brain fMRI response during performance of working memory tasks in adult patients with schizophrenia and major depressive disorder.Human brain mapping · 2021Pooled it
- Increased default-mode variability is related to reduced task-performance and is evident in adults with ADHD.NeuroImage. Clinical · 2017Trial
- Aberrant effective connectivity during working memory performance in schizotypal personality disorder and schizophrenia: A spectrum approach.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Methamphetamine-related working memory difficulties underpinned by reduced frontoparietal responses.Addiction biology · 2024Article
- Reduced coupling between offline neural replay events and default mode network activation in schizophrenia.Brain communications · 2023Article
- Decoding task specific and task general functional architectures of the brain.Human brain mapping · 2022Article
- Altered neural networks and cognition in a hereditary colon cancer.IBRO neuroscience reports · 2021Article
- Autobiographical memory and default mode network function in schizophrenia: an fMRI study.Psychological medicine · 2021Article
- Default Mode Network, Meditation, and Age-Associated Brain Changes: What Can We Learn from the Impact of Mental Training on Well-Being as a Psychotherapeutic Approach?Neural plasticity · 2019Review
- Polymorphism in schizophrenia risk geneNeuroImage. Clinical · 2018Article
- Altered intrinsic and extrinsic connectivity in schizophrenia.NeuroImage. Clinical · 2018Article
- Article
- Load-dependent hyperdeactivation of the default mode network in people with schizophrenia.Schizophrenia research · 2017Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSchizophrenia is associated with cognitive impairment and brain network dysconnectivity. Recent efforts have explored brain circuits underlying cognitive dysfunction in schizophrenia and documented altered activation of large-scale brain networks, including the task-positive network (TPN) and the task-negative default mode network (DMN) in response to cognitive demands. However, to what extent TPN and DMN dysfunction reflect overlapping mechanisms and are dependent on cognitive state remain to be determined.
methodsIn the current study, we investigated the recruitment of TPN and DMN using independent component analysis in patients with schizophrenia spectrum disorders (n = 29) and healthy controls (n = 21) during two different executive tasks probing planning/problem-solving and spatial working memory.
resultsWe found reduced load-dependent DMN deactivation across tasks in patients compared to controls. Furthermore, we observed only moderate associations between the TPN and DMN activation across groups, implying that the two networks reflect partly independent mechanisms. Additionally, whereas TPN activation was associated with task performance in both tasks, no such associations were found for DMN.
conclusionThese results support a general load-dependent DMN dysfunction in schizophrenia spectrum disorder across two demanding executive tasks that is not merely an epiphenomenon of cognitive dysfunction.
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