Evidence map›Paper›PMID 27622106›Full record

ArticlePlastic and reconstructive surgery. Global open2016

Hydrogel Delivery of Mesenchymal Stem Cell-Expressing Bone Morphogenetic Protein-2 Enhances Bone Defect Repair.

Hui-Yi Hsiao, Shu-Rui Yang, Eric M Brey, I-Ming Chu, Ming-Huei Cheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  5. Oncotarget · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Hui-Yi HsiaoDivision of Microsurgery Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Center for Tissue Engineering, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Ill.; and Research Service, Hines Veterans Administration Hospital, Hines, Ill.
Shu-Rui YangDivision of Microsurgery Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Center for Tissue Engineering, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Ill.; and Research Service, Hines Veterans Administration Hospital, Hines, Ill.
Eric M BreyDivision of Microsurgery Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Center for Tissue Engineering, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Ill.; and Research Service, Hines Veterans Administration Hospital, Hines, Ill.
I-Ming ChuDivision of Microsurgery Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Center for Tissue Engineering, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Ill.; and Research Service, Hines Veterans Administration Hospital, Hines, Ill.
Ming-Huei ChengDivision of Microsurgery Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Center for Tissue Engineering, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Ill.; and Research Service, Hines Veterans Administration Hospital, Hines, Ill.
Chang Gung Memorial Hospital · TWIllinois Institute of Technology · USNational Tsing Hua University · TW

Funding

Synthetic Matrices for Vascularization of Engineered TissuesI01BX000418 · VA · EDWARD HINES JR VA HOSPITAL · PI BREY, ERIC M · 2010 to 2017
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BLRD VA I01 BX000418
6 · The paper itself

Abstract

backgroundThe application of bone tissue engineering for repairing bone defects has gradually shown some satisfactory progress. One of the concerns raising scientific attention is the poor supply of growth factors. A number of growth factor delivery approaches have been developed for promoting bone formation. However, there is no systematic comparison of those approaches on efficiency of neobone formation. In this study, the approaches using periosteum, direct supply of growth factors, or gene transfection of growth factors were evaluated to determine the osteogenic capacity on the repair of bone defect.

methodsIn total, 42 male 21-week-old Sprague-Dawley rats weighing 250 to 400 g were used as the bone defect model to evaluate the bone repair efficiency. Various tissue engineered constructs of poly(ethylene glycol)-poly(l-lactic acid) (PEG-PLLA) copolymer hydrogel with periosteum, with external supply of bone morphogenetic protein-2 (BMP2), or with BMP2-transfected bone marrow-derived mesenchymal stem cells (BMMSCs) were filled in a 7-mm bone defect region. Animals were euthanized at 3 months, and the hydrogel constructs were harvested. The evaluation with histological staining and radiography analysis were performed for the volume of new bone formation.

resultsThe PEG-PLLA scaffold with BMMSCs promotes bone regeneration with the addition of periosteum. The group with BMP2-transfected BMMSCs demonstrated the largest volume of new bone among all the testing groups.

conclusionsAltogether, the results of this study provide the evidence that the combination of PEG-PLLA hydrogels with BMMSCs and sustained delivery of BMP2 resulted in the maximal bone regeneration.

Identifiers

PMID27622106
PMCPMC5010329
OpenAlexW2513013428

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.