ArticleAJP reports2016
Neurological Outcomes after Human Umbilical Cord Patch for In Utero Spina Bifida Repair in a Sheep Model.
Article in AJP reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- HC-HA/PTX3 from amniotic membrane reprograms human corneal fibroblasts to neural crest progenitors by switching from canonical to noncanonical TGFβ signaling.Stem cell research & therapy · 2026Article
- Dural substitutes for spina bifida repair: past, present, and future.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Review
- Prenatal Neural Tube Anomalies: A Decade of Intrauterine Stem Cell Transplantation Using Advanced Tissue Engineering Methods.Stem cell reviews and reports · 2022Review
- Allografts for Skin Closure during In Utero Spina Bifida Repair in a Sheep Model.Journal of clinical medicine · 2021Article
- Fetal myelomeningocele repair: a narrative review of the history, current controversies and future directions.Translational pediatrics · 2021Review
- A Novel Model of Fetal Spinal Cord Exposure Allowing for Long-Term Postnatal Survival.Fetal diagnosis and therapy · 2021Article
- Heritable spina bifida in sheep: A potential model for fetal repair of myelomeningocele.Journal of pediatric surgery · 2020Article
- Use of Human Umbilical Cord and Its Byproducts in Tissue Regeneration.Frontiers in bioengineering and biotechnology · 2020Article
- Spinal Angulation: A Limitation of the Fetal Lamb Model of Myelomeningocele.Fetal diagnosis and therapy · 2019Article
- The Science and Clinical Applications of Placental Tissues in Spine Surgery.Global spine journal · 2018Review
- Early neonatal loss of inhibitory synaptic input to the spinal motor neurons confers spina bifida-like leg dysfunction in a chicken model.Disease models & mechanisms · 2017Article
- Hydrogel and neural progenitor cell delivery supports organotypic fetal spinal cord development in anJournal of tissue engineeringArticle
- Advances in the prevention and prenatal treatment of spina bifida.Discoveries (Craiova, Romania)Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe objective of our study was to test the hypothesis that in utero repair of surgically created spina bifida in a sheep model using cryopreserved human umbilical cord (HUC) patch improves neurological outcome.
methodsSpina bifida with myelotomy was surgically created in timed pregnant ewes at gestational day (GD) 75. The fetuses were randomly assigned to unrepaired versus HUC and treated at GD 95 and then delivered at GD 140. Neurological evaluation was performed using the Texas Spinal Cord Injury Scale (TSCIS), bladder control using ultrasound, and the hindbrain herniation.
resultsThree lambs without the spina bifida creation served as controls. There were four lambs with spina bifida: two were unrepaired and two underwent HUC repair. The control lambs had normal function. Both unrepaired lambs had nonhealed skin lesions with leakage of cerebrospinal fluid, a 0/20 TSCIS score, no bladder control, and the hindbrain herniation. In contrast, both HUC lambs had a completely healed skin defect and survived to day 2 of life, a 3/20 and 4/20 TSCIS score (nociception), partial bladder control, and normal hindbrain anatomy.
conclusionsCryopreserved HUC patch appears to improve survival and neurological outcome in this severe form of the ovine model of spina bifida.
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